92. Peripheral Oxytocin and Vasopressin Modulates Regional Brain Activity Differently in Men and Women With Schizophrenia
Bibliographic record
Abstract
Background: Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing in healthy individuals. Abnormalities in these neuroendocrine systems are observed in schizophrenia and may contribute to deficits in cognition and emotion processing in a sex-dependent manner. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients relative to healthy controls. Methods: OT and AVP serum concentrations were assayed in 35 individuals with schizophrenia (12 women and 23 men) and 60 healthy individuals (36 women and 24 men) from the Chicago BSNIP study. Regional cerebral function was assessed with resting state fMRI by measuring the amplitude of low-frequency fluctuations (ALFF) that are believed to reflect spontaneous neuronal activity during rest. Results: AVP but not OT levels were lower in schizophrenia versus controls (P = .01). In women, higher OT levels were associated with higher ALFF in frontal and cerebellar cortices in patients (Ps < .05) versus controls. Higher AVP levels were also associated with lower ALFF in the superior temporal gyrus, anterior cingulate, and cerebellar cortex in patients (Ps < .05) versus controls. In men, higher OT levels were associated with higher ALFF in the posterior cingulate and higher AVP levels were associated with higher ALFF in the frontal cortex in patients (Ps < .05) versus controls. Furthermore, higher OT levels were associated with higher ALFF in the frontal cortex and lower ALFF in the thalamus in controls (Ps < .05) versus patients. In female patients, higher ALFF in frontal and cerebellar cortices were associated with poorer facial emotion recognition and higher ALFF in the frontal cortex was associated with poorer verbal fluency (Ps < .05). In male patients, higher ALFF in the thalamus was associated with poorer emotion recognition, verbal learning, and processing speed in male patients (Ps < .05), and higher ALFF in the posterior cingulate was associated with poorer verbal fluency (P < .05). Conclusion: Hormones differentially associate with brain networks important for cognition and emotion processing in men and women with schizophrenia. Associations with frontal and cerebellar cortices in female patients and the posterior cingulate in male patients may play sexually dimorphic roles in emotion processing and cognitive deficits in schizophrenia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".