Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr−/− mice
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
diabetes, cardiovascular disease, and hepatic steatosis, which collectively represent one of the leading causes of adult morbidity and mortality worldwide (1-3). This suggests that restoration of functional energy homeostasis is critical for therapeutic intervention. Despite efforts to develop anti-obesity medications that curtail symptoms of metabolic dysfunction, drugs that have reached the market have limited efficacy for obesity (5-8%) and many have been withdrawn for negative side effects (3-6). Currently available therapeutics predominantly work by either reducing caloric intake or blocking food absorption (3). Additionally, patients often regain lost weight. The treatment strategy with the most robust and lasting improvements is gastric bypass surgery, which has shown up to 25% weight loss at 12 years together with a 51% remission rate for type 2 diabetes (7). Presently, gastric bypass surgery as an intervention for obesity and metabolic syndrome is limited to patients with a BMI 35 kg/m 2 (8), excluding patients with moderate obesity, although these patients often present with increased metabolic dysfunction and cardiovascular risk (9, 10). Therefore, there is urgent need for safe and effective medical therapies for obesity and its associated complications, including the metabolic syndrome and cardiovascular disease.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it