Growing High Quality Plant Material for Natural Health Products
Bibliographic record
Abstract
Natural health products are commonly made from plant material in facilities where they can be stored for weeks to years. For stable ingredients, this process does not significantly change the phytochemical composition, but products with less stable bioactive phytochemicals such as melatonin are being introduced. Plant sourced melatonin, known as “phytomelatonin”, is the basis for a new line of nutraceuticals that are recommended for sleep disorders and anxiety. However, due to its lower stability, melatonin may have a short shelf-life. Therefore, methods to increase melatonin concentration in medicinal plants could provide better supplements. We hypothesized that varying light spectra changes melatonin and serotonin contents in tissues of Hypericum perforatum (St. John's Wort) and Scutellaria species (skullcap). Axenic cultures were exposed to red, blue, green or white light spectra provided by light emitting diode lighting systems, then serotonin and melatonin were quantified by ultra performance liquid chromatography-tandem mass spectrometry. Our data shows that in St. John's Wort, melatonin concentration is significantly affected by light spectra with the highest values in green light, and decreasing concentrations in the order of red, blue, white and fluorescent light (p < 0.001). In Scutellaria lateriflora and S. galericulata, the concentration of abscisic acid (ABA) was the highest under white light (p = 0.004 and p = 0.012, respectively). ABA concentration in S. galericulata had a decreasing trend under exposure of green, blue and red LED light. It is important to optimize the growth of plants as the demand for plant-based products grows. By optimizing the growth of the plant through the use of light, we can improve the medicinal chemical profile to improve products.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".