Multilevel Feature Representation of FDG-PET Brain Images for Diagnosing Alzheimer's Disease
Why this work is in the frame
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Bibliographic record
Abstract
Using a single imaging modality to diagnose Alzheimer's disease (AD) or mild cognitive impairment (MCI) is a challenging task. FluoroDeoxyGlucose Positron Emission Tomography (FDG-PET) is an important and effective modality used for that purpose. In this paper, we develop a novel method by using single modality (FDG-PET) but multilevel feature, which considers both region properties and connectivities between regions to classify AD or MCI from normal control. First, three levels of features are extracted: statistical, connectivity, and graph-based features. Then, the connectivity features are decomposed into three different sets of features according to a proposed similarity-driven ranking method, which can not only reduce the feature dimension but also increase the classifier's diversity. Last, after feeding the three levels of features to different classifiers, a new classifier selection strategy, maximum Mean squared Error (mMsE), is developed to select a pair of classifiers with high diversity. In order to do the majority voting, a decision-making scheme, a nested cross validation technique is applied to choose another classifier according to the accuracy. Experiments on Alzheimer's Disease Neuroimaging Initiative database show that the proposed method outperforms most FDG-PET-based classification algorithms, especially for classifying progressive MCI (pMCI) from stable MCI (sMCI).
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it