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Record W2885777890 · doi:10.11159/icbes18.1

Multi-Scale Modelling of Cerebral Blood Flow and its Control

2018· article· en· W2885777890 on OpenAlexvenueno aff
Stephen J. Payne

Bibliographic record

VenueProceedings of the World Congress on Electrical Engineering and Computer Systems and Science · 2018
Typearticle
Languageen
FieldMedicine
TopicTraumatic Brain Injury and Neurovascular Disturbances
Canadian institutionsnot available
Fundersnot available
KeywordsCerebral blood flowComputer scienceScale (ratio)MedicineCardiologyPhysics

Abstract

fetched live from OpenAlex

The human brain requires a continuous flow of blood in order to maintain the tight balance between supply and demand of nutrients (primarily oxygen and glucose). Cerebral blood flow is thus very tightly regulated, with impaired control being found in a wide range of cerebrovascular diseases. With the increasing prevalence of diseases such as dementia, and a growing appreciation of the importance of blood flow in these diseases, there is an urgent need to understand better how the brain controls blood flow across a wide range of length scales. In this talk, I will examine how these processes can be modelled, covering vessels from the large arteries to the capillary bed, and describe work under way to link these models directly to clinical imaging, so that we can gain a more direct measurement of cerebral blood flow control. I will also discuss ongoing work on translating this into clinical practice for the improved management of stroke patients and its potential implications in dementia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.944
Threshold uncertainty score0.269

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.213
Teacher spread0.198 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2018
Admission routes1
Has abstractyes

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