Toward the 2020 goal of soil-transmitted helminthiasis control and elimination
Bibliographic record
Abstract
Laboratory diagnosis of soil-transmitted helminthiasisChallenge: The global implementation of standard diagnostic tools based on microscopy (i.e., Kato-Katz technique) allowed comparison between countries, but these are not sensitive enough to be used in settings where elimination of soil-transmitted helminthiasis seems feasible and where infection intensities are low.Recommendation: Continue the development and validation of recent advances in PCR-based diagnostics for soil-transmitted helminthiasis and conduct rigorous, multisite evaluations, and strategic developments for larger-scale application in the field. Key item 9: Combination therapy for soil-transmitted helminthiasisChallenge: Preventive chemotherapy programs have increased considerably worldwide.Yet no single drug is equally effective in achieving satisfactory cure rates for the major soil-transmitted helminths, and drug resistance is expected to arise and further decrease the efficacy of available treatment options.Recommendation: The Committee appreciates both the efforts and challenges to developing coformulations of anthelmintic drugs and supports research initiatives that assess the safety and efficacy of various combination therapies in order to identify which combination is best suited for scaling up to achieve a maximum impact. Key item 10: Ownership of soil-transmitted helminthiasis control programsChallenge: Drug donation is the cornerstone of current soil-transmitted helminthiasis control efforts in many areas, but this is not a sustainable solution without a long-term perspective.Recommendation: Country ownership of soil-transmitted helminthiasis prevention and control programs is paramount, and future efforts should not rely on drug donation alone.Generic deworming drugs will become increasingly important post-2020, and WHO should encourage the prequalification of the manufacturers of these drugs. Key item 11: Foci of continued soil-transmitted helminthiasis transmissionChallenge: Guidance is required on how to deal with foci of ongoing transmission in areas where a regular preventive chemotherapy program is no longer being implemented.Recommendation: WHO should develop or endorse decision-making guidelines for program managers to identify and respond to foci of "unexpectedly high" soil-transmitted helminthiasis transmission post-preventive chemotherapy program.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.009 | 0.006 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.003 |
| Open science | 0.002 | 0.004 |
| Research integrity | 0.006 | 0.005 |
| Insufficient payload (model declined to judge) | 0.028 | 0.020 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".