Metabolomics: a tool to characterize the effect of phthalates and bisphenol A
Bibliographic record
Abstract
The study of physiological disruptions induced upon exposure to a given chemical substance has emerged as a research field. The assessment of the effects of chemical substances at low concentration levels is not always doable using classical toxicological studies. The use of metabolomics approaches integrated with conventional toxicological studies is expected to provide valuable information for risk assessment. This review recapitulates some of the recent publications related to the use of metabolomics to study the effect of bisphenol A (BPA) and phthalates exposure. Mass spectrometry and nuclear magnetic resonance metabolomics approaches revealed the principal metabolic pathways such as amino acids, energy storage compounds, or organic osmolytes were altered. To investigate phthalates and BPA effects is relevant to assist in potential correlations between exposure and adverse human effects and to provide data and evidence for effective regulatory policies and risk exposure assessment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.005 | 0.003 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".