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Record W2887779704 · doi:10.4212/cjhp.v50i2.2027

Danaparoid and the Prevention of Thromboembolism

2018· article· en· W2887779704 on OpenAlexvenueaboutno aff
W. R. Bartle, W. Geerts

Bibliographic record

VenueThe Canadian Journal of Hospital Pharmacy · 2018
Typearticle
Languageen
FieldMedicine
TopicVenous Thromboembolism Diagnosis and Management
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineGynecologyVenous thrombosisAntithromboticHeparinThrombosisSurgeryInternal medicine

Abstract

fetched live from OpenAlex

ABSTRACT Danaparoid (Orgaran ® ) has recently been marketed in Canada and is approved for the prevention of venous thrombosis following orthopedic, major abdominal and thoracic surgery; and following nonhemorrhagic stroke. Danaparoid is composed of heparin, dermatan, and chondroitin sulphates and exerts its anticoagulant effect by enhancing the activities of anti-thrombin III and heparin cofactor II. It is at least as effective as other thromboprophylaxis agents in the prevention of post-operative thrombosis. It has a low cross-reactivity rate with the antibody responsible for heparin-induced thrombocytopenia (HIT) and, thus, can be used with caution in patients who have developed HIT. RESUME Le danaparide (Orgaran ® ) a ete lance recemment sur le marche canadien et approuve dans la prevention de la thrombose veineuse consecutive a une chirurgie orthopedique,  abdominale importante ou thoracique, et a un ACV non hemorragique. Le danaparide est un compose d'heparane, de dermatane et de sulfates de chondroitine. Il exerce une action anticoagulante en accroissant l’activite de l'antithrombine III et du cofacteur II de d’heparine. Il est du moins aussi efficace que d'autres agents thromboprophylactiques pour prevenir les thromboses post-operatoires. Son taux de reactivite croisee avec l'anticorps responsable de la thrombocytopenie musee par l'heparine est faible et peut donc etre utilise avec circonspection chez les patients chez qui s'est developpe cette condition.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.293
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2018
Admission routes2
Has abstractyes

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