Geohelmintiasis e hiper-IgE en escolares de un área rural y un área urbana de Honduras entre septiembre 2014 a junio 2015
Bibliographic record
Abstract
Introduction: Helminths transmitted by the soil (geohelminths) are the intestinal parasites that provoke the polarization of the immune system towards a response characterized by the high circulating values of Immunoglobulin E (IgE). In Honduras, there are no recent studies demonstrating this biological phenomenon.Objectives: This study aims to determine the association between geohelminth infections with hyper- IgE, comparing schoolchildren from a rural area and an urban area of Honduras.Methodology: Descriptive transversal study. Two communities were selected, with a high prevalence of geohelminths (> 50%) and an urban with low prevalence of geohelminths (<20%). Interviews were conducted with the participants to determine their age, grade and history of deworming. To determine the prevalence of parasites, faecal samples were collected and processed with the Kato-Katz Method and Ethyl Acetate. To determine serum IgE levels, blood samples were taken, and the serum was processed using MagPIX® technology (human Bio-Plex Pro_IgE kit). According to this method the limit of detection for IgE is 0.040 ng / ml. Ethical approval CEI/MEIZ. Parametric and non-parametric statistical analysis.Results: 73 children from the rural area and 71 from the urban area were studied, of which 35 (47.9%) and 5 (7%) were parasitized with one or more species of geohelminths (Trichuris trichiura, Ascaris lumbricoides, hookworm) respectively. Eight participants (<6%) had moderate to severe infections. The rural population presented 94.5% (69) of hyper-IgE in contrast to the urban population with 63.5% (45), (p <0.001). Limitations: there is no history of allergic processes related to IgE.Conclusions: This study was able to determine that there is a significant difference in the IgE levels of children with geohelminth parasites between rural and urban populations. This may explain the decline in allergic reactions in older populations.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".