Abstract 14601: Vegetarianism is Independently Associated With Lower Risk of Left Ventricular Diastolic Dysfunction and Stage B Heart Failure Burden
Bibliographic record
Abstract
Introduction: Heart failure (HF) affects about 6 million Americans at an annual direct cost of $40 billion. Left ventricular (LV) diastolic dysfunction and stage B HF are predictors of clinical HF and reduction of stage B HF burden may help reduce HF disease burden in the community. In our Adventist Health Study-2 (AHS-2) of 96,000 subjects, a vegetarian compared to a non-vegetarian diet was associated with lower body mass index, and risk of diabetes and hypertension despite similar caloric intake. Hypothesis: We hypothesized that vegetarianism would also lead to a lower risk of LV diastolic dysfunction and stage B HF. Methods: We invited a random sample of 206 subjects from AHS-2 stratified by diet (vegetarians, lacto-ovo vegetarians, pescovegetarians and nonvegetarians), aged >60 years and living within 50 miles of Loma Linda for a clinic visit consisting of a history, anthropometrics, blood pressure measurement, food frequency questionnaire and a full echocardiogram. LV volume, EF, wall motion, diastolic function and mass and left atrial size were assessed based on guidelines of American society of Echocardiography. Results: The mean age was 74 (10) years, 49% were males and subjects were equally distributed in 4 food groups. LV diastolic dysfunction was present in 60%, LV hypertrophy in 10%, LVEF <50% in 5% and increased left atrial volume index in 45% of the subjects. After adjusting for age, gender, race, body surface area, prevalent MI, diabetes and hypertension, a vegan diet (no animal products), compared to non-vegetarian diet, was associated with a lower prevalence of LV diastolic dysfunction (OR 0.42, 95% CI 0.24-0.73) and LV hypertrophy (OR 0.30, 95% CI 0.08-0.86) Vegetarians also had a lower number of stage A risk factors and stage B components (p<0.05). There was a trend towards graded increase in risk of stage B HF with increasing degree of nonvegetarianism. Conclusions: A vegan diet is independently associated with lower risk of LV diastolic dysfunction, LV mass and stage B HF burden.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.010 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".