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Record W2888690944

The Emerging Role of the Microbiome in Precision Medicine: a review

2017· review· en· W2888690944 on OpenAlexvenueno aff
Leah Kosyakovsky

Bibliographic record

VenueUBC Faculty of Medicine medical journal · 2017
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGut microbiota and health
Canadian institutionsnot available
Fundersnot available
KeywordsMicrobiomeIdentification (biology)Context (archaeology)Personalized medicinePrecision medicineDiseaseMedicineHuman microbiomeHuman diseaseBioinformaticsComputational biologyData scienceEngineering ethicsPathologyBiologyComputer scienceEngineering
DOInot available

Abstract

fetched live from OpenAlex

The advent of precision medicine has promoted an influx of research relating to the identification of patient-specific factors, both genetic and acquired, which could be targeted and manipulated in the context of disease. The microbiome is a particularly good example of a potential target of these measures, as it represents a diverse array of unique, manipulable factors that is known to play an important role in both normal human physiology and the development of pathology. Given this, the contribution of the microbiome to human disease, as well as the potential utilization of microbial modulation in prevention and treatment, is a burgeoning area of study. In this review, we will consider the advancements that have already been made in our understanding of the role of the microbiome in the fields of cardiology, immunology, psychiatry, and oncology, as well as assess what further research is required to enable the application of these findings to the world of personalized medicine.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.006
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.903
Threshold uncertainty score0.698

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0060.006
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0020.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.053
GPT teacher head0.425
Teacher spread0.373 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2017
Admission routes1
Has abstractyes

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