The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity
Bibliographic record
Abstract
The McGill-R-Thy1-APP transgenic rat is an animal model of the familial form of Alzheimer’s disease (AD), mirroring many neuropathological hallmarks of the disease and gradual deterioration of cognitive functions. In this study, we describe thorough characterization of the model in several domains. On the behavioral level, we report normal locomotor activity in spontaneous exploration, but problems with balance or gait coordination, increased anxiety and severely impaired spatial cognition in 4 - 7 months old animals. The profile of social behavior and ultrasonic communication is altered in the McGill rats, without a general social withdrawal. McGill rats also exhibit changes in circadian profile, with shorter free-running period and increased total activity during subjective night, without signs of sleep disturbances during the inactive phase. Expression of circadian clock gene Bmal1 was found to be increased in the parietal cortex and cerebellum, while Nr1d1 expression was not changed. The clock-controlled gene Prok2 expression was found to be elevated in the parietal cortex and hippocampus, which might contribute to the observed changes in circadian phenotype. We conclude that the AD-like phenotype in the rat model is not restricted to cognitive domain, but also includes gait problems, changes in emotionality, social behavior and circadian profiles, paralleling the spectrum of symptoms observed in human patients and enabling development of new therapeutic approaches targeting not only memory decline but also other symptoms decreasing the quality of life of the patients.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".