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Record W2889449548 · doi:10.3389/fmicb.2018.02161

Addressing Global Ruminant Agricultural Challenges Through Understanding the Rumen Microbiome: Past, Present, and Future

2018· review· en· W2889449548 on OpenAlexaff
Sharon Huws, Christopher J. Creevey, Linda Oyama, Itzhak Mizrahi, Stuart E. Denman, Milka Popova, Rafael Muñoz‐Tamayo, Évelyne Forano, Sinéad M. Waters, Matthias Hess, Ilma Tapio, Hauke Smidt, S.J. Krizsan, David R. Yáñez-Ruíz, Alejandro Belanche, Leluo Guan, Robert J. Gruninger, Tim A. McAllister, C. J. Newbold, R. Roehe, R.J. Dewhurst, Tim Snelling, Mick Watson, Garret Suen, Elizabeth H. Hart, Alison H. Kingston‐Smith, N.D. Scollan, Rodolpho Martin do Prado, Eduardo Jorge Pilau, Hilário Cuquetto Mantovani, Graeme T. Attwood, Joan E. Edwards, Neil McEwan, Steven Morrisson, Olga Lucía Mayorga, Christopher L. Elliott, Diego Morgavi

Bibliographic record

VenueFrontiers in Microbiology · 2018
Typereview
Languageen
FieldAgricultural and Biological Sciences
TopicRuminant Nutrition and Digestive Physiology
Canadian institutionsAgriculture and Agri-Food CanadaUniversity of Alberta
FundersBiotechnology and Biological Sciences Research CouncilHorizon 2020 Framework ProgrammeNational Institute of Food and AgricultureDirectorate for Biological SciencesNederlandse Organisatie voor Wetenschappelijk OnderzoekEuropean CommissionU.S. Department of AgricultureScottish GovernmentScotland’s Rural CollegeConselho Nacional de Desenvolvimento Científico e TecnológicoRural and Environment Science and Analytical Services Division
KeywordsRumenMicrobiomeBiologyArchaeaBiotechnologyMetagenomicsAgriculturePopulationRuminantLivestockEcologyBacteriaFood scienceBioinformaticsPastureGeneGenetics

Abstract

fetched live from OpenAlex

The rumen is a complex ecosystem composed of anaerobic bacteria, protozoa, fungi, methanogenic archaea and phages. These microbes interact closely to breakdown plant material that cannot be digested by humans, whilst providing metabolic energy to the host and, in the case of archaea, producing methane. Consequently, ruminants produce meat and milk, which are rich in high-quality protein, vitamins and minerals, and therefore contribute to food security. As the world population is predicted to reach approximately 9.7 billion by 2050, an increase in ruminant production to satisfy global protein demand is necessary, despite limited land availability, and whilst ensuring environmental impact is minimized. Although challenging, these goals can be met, but depend on our understanding of the rumen microbiome. Attempts to manipulate the rumen microbiome to benefit global agricultural challenges have been ongoing for decades with limited success, mostly due to the lack of a detailed understanding of this microbiome and our limited ability to culture most of these microbes outside the rumen. The potential to manipulate the rumen microbiome and meet global livestock challenges through animal breeding and introduction of dietary interventions during early life have recently emerged as promising new technologies. Our inability to phenotype ruminants in a high-throughput manner has also hampered progress, although the recent increase in "omic" data may allow further development of mathematical models and rumen microbial gene biomarkers as proxies. Advances in computational tools, high-throughput sequencing technologies and cultivation-independent "omics" approaches continue to revolutionize our understanding of the rumen microbiome. This will ultimately provide the knowledge framework needed to solve current and future ruminant livestock challenges.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0030.007
Open science0.0010.003
Research integrity0.0040.003
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.109
GPT teacher head0.305
Teacher spread0.196 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations528
Published2018
Admission routes1
Has abstractyes

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