RF26 The effectiveness of physical actvitiy interventions for people with osteoarthritis and comorbidity: a meta-analysis of obesity
Bibliographic record
Abstract
<h3>Background</h3> Osteoarthritis (OA) is one of the diseases with the highest prevalence of comorbidity. Clinical guidelines recommend physical activity (PA) for people with OA irrespective of comorbidity. Research investigating the effectiveness of PA interventions in OA and comorbidity is needed. Objective: To synthesise existing evidence investigating the effectiveness of PA interventions in adults with OA and obesity. <h3>Methods</h3> A systematic review with meta-analysis was conducted (PROSPERO Registration: CRD42017055582). Six electronic databases; MEDLINE, EMBASE, AMED, CINAHL, SportDiscus and CENTRAL were searched for studies from their inception to 29.03.17. Inclusion criteria were: randomised controlled trials (RCTs) comparing the effectiveness of any PA intervention to non-PA control group; including adults aged 45 years old and over with clinical or radiographic OA at any site; at least one of the comorbidities of interest (COPD, depression, diabetes, hypertension, obesity, T2DM); and measuring pain, physical function, quality of life, global health post intervention and adverse events. Included study risk of bias (ROB) was assessed using the Cochrane risk of bias tool. Two reviewers screened titles, abstracts and full text articles, checked data extraction, and carried out ROB assessment. Random-effects model meta-analysis pooled outcomes from sufficiently homogeneous studies to calculate effect sizes (Standardized Mean Difference (SMD) with 95% confidence interval (CI)). Meta-analysis findings of the OA and obesity subgroup are reported. <h3>Results</h3> The literature search retrieved 8171 citations of which 14 studies (n=4224 participants) were included in the full review, with 9 (n=1382 participants) analysed in the OA and obesity subgroup. PA interventions included: aquatic, aerobic, strengthening and functional activity; of 1–18 months in duration. Four studies of OA and obesity measuring either Western Ontario Osteoarthritis Index (WOMAC) pain, WOMAC function or Six Minute Walking Test (6 MWT) and were included in three meta-analyses. Best estimates showed PA to improve WOMAC pain (n=3 studies; n=547 participants; SMD=-0.09 (95% CI) −0.65, 0.47), improve WOMAC function (n=3 studies, n=415 participants; SMD=-0.35 (95% CI) −0.89, 0.18) and the 6 MWT (n=4 studies, n=573 participants; SMD=-0.93 (95% CI) −0.49, 2.35). However, results were not statistically significant. There was substantial between-trial outcome heterogeneity (I²=89.4% (p=0.000); 77.5% (p=0.012); 97.8% (p=0.000); respectively); results should be interpreted with caution. ROB domain judgements were generally either low or unclear. A small minority of judgements were at high risk of bias. <h3>Conclusion</h3> Best estimates suggest small beneficial effects of physical activity on WOMAC pain, WOMAC function and the 6 MWT. Mixed effectiveness among individual RCTs was likely due to heterogeneous intervention types, intensity and duration.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".