A Novel Role for the PKG‐encoding <i>foraging</i> Gene in the Fly ‘Pancreas’ of <i>Drosophila melanogaster</i>
Bibliographic record
Abstract
The Drosophila melanogaster corpora cardiaca (CC) is functionally homologous to the mammalian pancreatic alpha cells and anterior pituitary gland. The CC is the site of biosynthesis and secretion of the fly glucagon homolog, adipokinetic hormone (AKH). The foraging gene ( for ) in D. melanogaster encodes a cGMP‐dependent protein kinase (PKG) and is evolutionarily conserved across taxa. for has a well‐established role in the regulation of feeding behavior and metabolism. Here we identify a CC‐specific role for for in the regulation of adult feeding behavior, lipid metabolism, and starvation stress response. The expression of transgenic for ‐RNAi constructs specifically in the CC significantly decreases adult whole body lipid content and starvation resistance, and increases adult feeding behavior. Immunohistochemistry data suggest that the transgenic manipulation of for in the CC alters the secretion of AKH. By restricting the CC‐specific transgenic manipulation of for to precise developmental periods, we demonstrate that the effects on adult metabolism and feeding behavior have their origin in juvenile life. These data demonstrate a novel role for foraging and PKG in the CC, and begin to elucidate a putative mechanism whereby juvenile experience can influence adult metabolism and health outcomes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".