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Record W2891587993 · doi:10.1016/j.cmet.2018.09.001

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

2018· article· en· W2891587993 on OpenAlexafffund
Laura Hulea, Simon‐Pierre Gravel, Masahiro Morita, Marie Cargnello, Oro Uchenunu, Young Kyuen Im, Camille Lehuédé, H. Eric, Matthew Leibovitch, Shannon McLaughlan, Marie‐José Blouin, Maxime Parisotto, Vasilios Papavasiliou, Cynthia Lavoie, Ola Larsson, Michael Ohh, Tiago Ferreira, Celia M.T. Greenwood, Gaëlle Bridon, Daina Avizonis, Gerardo Ferbeyre, Peter M. Siegel, Russell G. Jones, William J. Muller, Josie Ursini‐Siegel, Julie St‐Pierre, Michaël Pollak, Ivan Topisirović

Bibliographic record

VenueCell Metabolism · 2018
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer, Hypoxia, and Metabolism
Canadian institutionsUniversity of OttawaMontreal General HospitalUniversity of TorontoUniversité de MontréalMcGill University Health CentreMcGill University
FundersFonds de Recherche du Québec - SantéNatural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health ResearchNational Cancer InstituteNational Institutes of HealthTerry Fox Research InstituteMinistry of Education, Culture, Sports, Science and TechnologyFondation du cancer du sein du QuébecCanada Foundation for InnovationTerry Fox FoundationMcGill University
KeywordsmTORC1GlutamineBiguanideCancer cellGlutaminolysisAsparagineBiologySerineCancerBiochemistryCancer researchPI3K/AKT/mTOR pathwayAmino acidSignal transductionEnzymeEndocrinology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.531
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.254
Teacher spread0.241 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations89
Published2018
Admission routes2
Has abstractno

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