Performance effects of feed-borne Fusarium mycotoxins on broiler chickens: Influences of timing and duration of exposure
Bibliographic record
Abstract
In commercial practice, broiler chickens may be exposed to Fusarium mycotoxins either during specific growth stages or throughout the entire production cycle. A 34-day feeding trial was conducted to identify sensitive periods for mycotoxin effects during the growth cycle of broiler chickens. A total of 420 newly-hatched Ross 308 male broilers were randomly assigned to 60 cages with 7 birds/cage. Sources of clean wheat (<0.5 mg/kg deoxynivalenol [DON]) and Fusarium-contaminated wheat (11.4 mg/kg DON) were used to formulate the starter diets (0.41 and 6.62 mg/kg DON) provided from 1 to 21 d of age and the grower diets (0.54 and 7.90 mg/kg DON) provided from 22 to 34 d. Control and DON diets were provided to broilers according to treatments (control, DON 1 to 14 d, DON 15 to 21 d, DON 22 to 34 d and DON 1 to 34 d). Birds were monitored daily for morbidity or mortality. Broiler growth performance (body weight, average daily gain, average daily feed intake and feed to gain ratio) was measured weekly. Segments of duodenum, jejunum and ileum were collected at 21 and 34 d and morphometric parameters (villus height, crypt depth, villus width, muscularis thickness and villi:crypt ratio) were measured. Birds fed the DON starter diet during the first 14 d did not exhibit any changes in growth performance; however, growth performance was suppressed in birds fed DON-contaminated diets during the grower period (22 to 34 d). At 34 d, birds that received the DON grower diet (DON 22 to 34 d and DON 1 to 34 d) were lighter (1,433 vs. 1,695 g) than birds fed the control diet. Feed to gain ratio was higher in birds fed the DON grower diet from 22 to 28 d (1.77 vs. 1.56) and 28 to 34 d (2.24 vs. 1.85) compared with corresponding controls. These results suggest that providing older broiler chicks (22 to 34 d) feed contaminated with Fusarium mycotoxins (specifically DON) may result in production losses. Histopathological analysis of the ileum region revealed that birds provided the DON diets throughout the entire trial (1 to 34 d) had shorter villi (506 vs. 680 μm) and shallower crypt (85 vs. 115 μm) than control birds. Taken together, these results indicate that DON-induced growth suppression may be a result of adverse effects on intestinal morphology during later growth phases of broilers.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".