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Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial
Erin A. Bohula, Benjamin M. Scirica, Silvio E. Inzucchi, Darren K. McGuire, Anthony Keech, Steven R. Smith, Estella Kanevsky, Sabina A. Murphy, Lawrence A. Leiter, Jamie P. Dwyer, Ramón Corbalán, Christian W. Hamm, Lee M. Kaplan, José Carlos Nicolau, Ton Oude Ophuis, Kausik K. Ray, Mikhail Ruda, Jindřich Špinar, Tushar Patel, Wenfeng Miao, Carlos Perdomo, Bruce H. Francis, Shobha Dhadda, Marc P. Bonaca, Christian T. Ruff, Marc S. Sabatine, Stephen D. Wiviott, Andrew Satlin, Conville Brown, Andrzej Budaj, Armando García-Castillo, Milan Gupta, Kauski Ray, Neil J. Weissman, Harvey D. White, John Amerena, Margaret Arstall, David Colquhoun, Rohan Jayasinghe, A Lee, Richard Lehman, Robert G. Moses, Joeseph Proietto, P Purnell, J. Waites, Peter Blombery, DeWitte T. Cross, M. Worthley, Michael C dʼEmden, Joseph B. Selvanayagam, RE Oqueli, Alexandra Whelan, P. Garrahy, Fred de Looze, Daniel M. Ninio, John D. Horowitz, Maged William, Michael Suranyi, Gary Wittert, M. Le May, AS Pandey, Saul Vizel, Rachel C. Labonte, Y Beaudry, Claude Fortin, Avery Davis Bell, Simon Kouz, Eric St-Amour, Iqbal Bata, François Maurice, R Chehayeb, Christian Constance, Grace Lai‐Hung Wong, Joanne Liutkus, P. Poirier, Isaac Teitelbaum, Joseph Berlingieri, Jinah Cha, M Hartleib, M Heffernan, David Twum-Barima, V Pandith, Ronnie Aronson, Ronald Goldenberg, Buki Ajala, Ajay Jain, Samir A. Ross, Harpreet S. Bajaj, Hasnain Khandwala, Zeina Yared, Nikita Gupta, Jacques Bédard, Sean Wharton, François Blouin, Dillon Savard, D Shukla, J. Covarrubias Cobos, Gustavo Pina Godoy, Laura M. Pérez, Christian Pincetti, V Saavedra Guajardo, Paola Varleta, C. Conejeros, Fernando Laņas, Edmundo-Alfredo Bayram Llamas, Elena Muñoz, Ronald G. García, Jose Garza Ruiz, G Llamas Esperon, E Lopez Rosas, Gladys Ramos, Huberta E. Hart, D. Scott, Ian Ternouth, Jocelyne Benatar, J Elliott, Richard Cutfield, Patrick Manning, Mandy Williams, Katherine Ferrier, Russell Scott, Sean R. Wilson, R Leikis, BK Nirmalaraj, Ewa Krzyżagórska, Paweł Miękus, Marek Bronisz, Ewa Mirek-Bryniarska, Karenia Landa, Arkadiusz Stasiewski, Tadeusz Żechowicz, D Zytkiewicz-Jaruga, Janusz Korecki, Mateusz Ogórek, Lidia Pawłowicz, Marek Piepiorka, Joanna Skierkowska, Andrzej Stankiewicz, Ewa Szyprowska, Robert Witek, Andrzej Bochenek, Piotr Kończakowski, Lukasz Wojnowski, Marek Wujkowski, Krzysztof Cymerman, Romuald Korzeniak, Patricia Mader, Beata Mikłaszewicz, P Stachlewski, Aleksander Goch, Witold Pomiecko, Maciej Skórski, Leszek Romanowski, K Jusiak, Ewa Laskowska-Derlaga, Renata Bijata-Bronisz, Jarosław Kaźmierczak, Ronald Goldberg, Doug Henderson, Elie H. Korban, Klaus Röhr, Edmund Claxton, Ram Weiss, Dominick J. Angiolillo, Fernando Boccalandro, Kon Chu, Elizabeth Thorn, Premjit S. Randhawa, Narendra Singh, George Bittar, Thomas Guarnieri, Saqib Saeed, Susmeeta T. Sharma, Mary A. Shepard, William P. French, Prakash M Desai, Robert M. Bernstein, William Rogers, Rikki Singal, R Schneider, J Shanes, S.H. Ong, Jonathan Condit, Sean M. Donahoe, David Brill, Daniel Einhorn, R Toupa Ebrahimi, Ajay Labroo, Rolf Graf, John D. Scott, Joost Hoekstra, Prasad Jetty, Gary J. Luckasen, Peter H. O’Donnell, W Gonte, Daniel Pomposini, Mark Quadrel, Michael Koren, David Schlager, Erichn L Schramm, D Singal, Steven Lupovitch, Anil Kumar Soni, P Seigel, John Roberts, Joseph Soufer, Erin Burke Quinlan, T Moretto, Brian First, Raihan Khan, S Chilka, Harry T. Colfer, Andrew Teklinski, K Wallace-Wilding, Howard Ellison, Derek Muse, S Aronoff, Alexander Higgins, Shivani A. Patel, Victor Elinoff, Asra Karim, Vivek Awasty, Rosa Chuang, Hal Roseman, P Dugano-Daphnis, Michelle A. Albert, Karen L. Sheikh, Harold Bays, S. Kaster, Michaela Goldstein, Domenica Rubino, G. Calatayud, Heather M. Snyder, Thomas N. Williams, Kenneth S. Hershon, Miriam Hagan, Steven Isserman, BB Kahn, J. Anderson, MP Gimness, Ajit Raisinghani, M. Fallgren Christina, Marina Raikhel, Elizabeth Gillespie, Edward L. Portnay, Mark L. Heiman, M. S. Qureshi, Jongmin Lee, Ronald Blonder, F Cucher, Gary Miller, D Kotlaba, George Mitchell Cornett, Jill E Beavins, Charles Augenbraun, Samuel W. Reinhardt, A. Bartkowiak, Abraham Salacata, Thomas Blevins, Sophiya Benjamin, Jürgen Diener, William H. George, B Barker, Randall Richwine, Daniela Baldari, Anna B. Alfieri, Andrew D. Barreto, Lin Zhang, Reema Shah, Emile A. Hendrix, Vivekanandhan Subramaniyam, Sinéad Hurley, Michael Lillestol, Michelle L. O’Donoghue, Sepideh Shayani, Eileen Ryan, Robert S. Call, Lawrence Zemel, Angela Chang, A. Kivitz, Bridget Freyne, V.C. Bland, Karen Shore, E Mostel, E Uzoaga, Nabil Andrawis, Nashwa Gabra, Arnold Ghitis, Kenneth Sabatino, David Browder, S. Varma, Raymond Fink, GR Aycock, W. Daniel Doty, T Alfonso, Shahrooz Eshaghian, Ronald P. Karlsberg, Stuart Zarich, C. Landau, Michael J. McKenzie, Richard A. Krause, William B. Davis, Tamer Haddad, Steven Voyce, C. Alford, Jean‐Baptiste Ledoux, David O’Dea, Jung Wook Park, Vanita R. Aroda, Abush Getaneh, B Graham, Ravi Bhagwat, Darlene Korn, Gary Ruoff, Alan Wiseman, Ira Lieber, Jonathan Fialkow, J. Michael González-Campoy, Carlos Bayron, Barry Bertolet, J A Lash, Christopher Gerrish, David L. Robertson, Jeffrey Rosenfeld, M Seidner, John Agaiby, Joel C. Silverfield, Danny Sugimoto, B. Lubin, M Alhaddad, Henry Lui, Gregory E. Lakin, Sagar Chokshi, Dennis M. Donovan, William R. Felten, S. Minton, Carey Kimmelstiel, Jeffrey T. Kuvin, Christopher D. Still, William Byars, Julie‐An Talano, V K Desai, AJ Bradley, Scott Baker, Majed Chane, Anita Mercado, Stefan Baron, Breanne Harris, Nick Mayer, Mauricio Concha, Kenneth D. Carr, Louis Chaykin, J. Willis, Adam Clay, Eric R. Fenstad, J Furda, Patrick Peterson, Min Jung Chang, Louis J. Aronne, Daniel A. Jones, Rakesh Prashad, Mark D. Benson, R Stegemoller, K Longshaw, Julian Saleh, William Jennings, Robert Detweiler, Deepak Viswanath, R Patel, Samuel Lederman, D. Weinstein, Ravi Korabathina, Vikram Singh, Jonathan Rosen, Roberto Estévez, Philip Levin, R McNeill, V Kalen, Josh Reed, Robert Ashley, Levente Hermán, Yi‐Wen Tsai, David Kayne, Alexander White, Irshad Hussaın, Luis Tami, K. L. Cohen, J. Robinson, Debra Fuchs‐Ertman, Geraldine Quintero Platt, Lorena Belardo, R. Sneha Latha Reddy, Clive Rosendorff, Fadi Saba, Steve Powell, Kim Anderson, Muneer H. Abidi, Shereif H. Rezkalla, Alexander Paraschos, Jessica R. Wilson, Mahmoud Moursi, A. Shah, Venkatesh Nadar, Larry D. Stonesifer, Martin R. Bialow, K Cannon, W. Ellison, Mike Stedman, Judith C. Brown, Wayne L. Harper, K.B. Lucas, Michael P. DiGiovanna, Helena W. Rodbard, M Biscoveanu, Chandra Davis, Julien Hall, R Littlefield, Tracy Gorman, Dean J. Kereiakes, Chang Fm, Horia Tatu, D. Cheung, Jeffrey Kaine, Tomas Knutson, Tim Logemann, G Pueblitz, J Bianco, Brad Henson, M Neustel, M. Gelernt, Warrick Nelson, Kieran Moriarty, Gigi Lefebvre, K Maw, Lothar Rink, P Behn, H Studdard, Georges Argoud, Thomas P. O’Connor, Perry Krichmar, George Raad, J Pereles-Ortiz, Christopher Sorli, Allan Cohen, Karlton Pettis, B Cavanaugh, Ceri Phillips, Jack Wahlen, Dean Radin, Jennifer R. Rider, Edward Kosinski, Wayne Leimbach, Ashika Odhav, Joseph Hakas, Anjanette Tan, Michael Howell, Duane G. Wombolt, Norman Fishman, Pallav L. Shah, Peter Wylie, Carlos Arauz-Pacheco, Arvind R. Cavale, A George, Robin Kroll, J Krantzler, Naeem Khan Tahirkheli, M Jabro, M. Newell, Paul Mullen, N Gencheff, J. Meli, K Vora, Larry Kotek, K. L. Pyzdrowski, Herrera Páez, Joseph Moran, Alexander Tannenbaum, Kenneth Deck, Robert S. Busch, L Levinson, Masoud Azizad, J. Steve Whitaker, Bianca Passos Fox, C.F. Huffman, M Javed Ashraf, José Diogo, Robert F. Kushner, J Tallet, V Channamsetty, David Suh, Jesús Navas, V. Leroy Young, S. Shaw, Isaac Dor, B. L. Duffy, Paul Rubin, David Lewis, Walter H. Kaye, Robert J. Benton, Jose Burbano, David R. Hotchkiss, Aaron L. Magno, Anm Alberton, Judith Collins, Olivia Sanhueza Alvarado, Mark A. Stich, S Mahal, Jie Liu, Myeong‐Ki Hong, J Dy, Bradley Block, Jamie N. LaMantia, Jessica H Pritchard, Matthew Davis, Sunny Srivastava, Seth Bilazarian, Reinaldo Rosario, Margaret McCartney, V Blumberg, Roopa Rajan, Eleanor Martin, Stephen Wright, Cynthia Brinson, J.H. Johnston, M C Graves, Mariah C. Dominguez, William McKenzie, Rafik Abadier, Christian Tran, Roberto Castello, Emily Morawski, Julia White, Felicity Anne Morris, Antonio Pérez, P Trueba, María‐José Sánchez, J Andersen, Rebeka Kastelic, Junaid Khan, Henry Rodriguez, W Izquierdo, Abigair Duarte Matias, Louis Essandoh, Can İnce
Bibliographic record
VenueThe Lancet · 2018
Typearticle
Languageen
FieldMedicine
TopicPharmacology and Obesity Treatment
Canadian institutionsUniversity of TorontoSt. Michael's Hospital
Fundersnot available
KeywordsMedicineInternal medicinePrediabetesOverweightDiabetes mellitusPlaceboHazard ratioType 2 diabetesClinical endpointBody mass indexRandomized controlled trialPhysical therapyEndocrinologyConfidence interval
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.028
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.006 | 0.003 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.004 |
| Insufficient payload (model declined to judge) | 0.008 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.012
GPT teacher head0.307
Teacher spread0.295 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations95
Published2018
Admission routes1
Has abstractno