NURIP: Neural Interface Processor for Brain-State Classification and Programmable-Waveform Neurostimulation
Why this work is in the frame
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Bibliographic record
Abstract
The advancement of implantable medical devices for the treatment of neurological disorders demands energy-efficient, low-latency processors for responsive, safe, and personalized neuromodulation. A 130-nm CMOS neural interface processor is presented to perform the brain-state classification and closed-loop control using programmable-waveform electrical stimulation. The architecture features an autoencoder neural network for both spatial filtering and dimensionality reduction. Dedicated feature extraction blocks are implemented for univariate (signal-band energy) and multivariate (phase locking value, and cross-frequency coupling) neural signal processing. The proceeding exponentially decaying memory support vector machine (EDM-SVM) accelerator employs these features for hardware-efficient brain-state classification with a high temporal resolution. An integrated digitally charge-balanced waveform generator enables flexibility in finding optimal neuromodulation paradigms for pathological symptom suppression. The system on chip (SoC) is validated using the EU human intracranial electroencephalography epilepsy data set, achieving a seizure sensitivity of 97.7% and a false detection rate of 0.185/h while consuming 169 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{J}$ </tex-math></inline-formula> per classification.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it