Retinopathy of Prematurity and Multiple Postnatal Infections in Preterm Neonates: Delays in White Matter Development with Poorer Neurodevelopmental Outcomes
Bibliographic record
Abstract
Preterm birth is a common cause of neurodevelopmental disorders in childhood. Little is known about the outcome of infants with severe retinopathy of prematurity (ROP) and multiple infections in the postnatal period. This thesis describes their associations with abnormal brain development using multi-modal MR imaging and standardized outcome assessments. Those infants with severe ROP had delayed brain maturation of the posterior white matter and optic radiations, with poorer 18 month cognitive and motor outcomes. Compared to fewer episodes of infection, three or more postnatal infections was associated with delayed maturation of the posterior limb of the internal capsule (PLIC), corpus callosum and the optic radiations, with poorer 36 month motor outcomes. Our findings support that severe ROP and multiple postnatal infections in very preterm newborns are associated with decreased brain maturation and poorer neurodevelopmental outcomes, and that advancements in these disorders have the potential to improve outcomes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".