Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
VenueNature Communications · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEpigenetics and DNA Methylation
Canadian institutionsUniversité LavalMemorial University of NewfoundlandUniversity of AlbertaSinai Health SystemUniversity of British ColumbiaMcGill UniversityCanada Research ChairsQueen's UniversityBC Cancer AgencyVancouver General HospitalPrincess Margaret Cancer CentreMount Sinai HospitalLunenfeld-Tanenbaum Research InstituteCentre hospitalier universitaire de QuébecRoyal Victoria HospitalUniversity Health NetworkUniversity of Toronto
FundersDivision of Cancer Epidemiology and Genetics, National Cancer InstituteMedical Research and Materiel CommandNational Institute of Diabetes and Digestive and Kidney DiseasesFogarty International CenterNational Institute of General Medical SciencesNational Human Genome Research InstituteNational Institute on Drug AbuseNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Institute on AgingServicio Gallego de SaludOntario Ministry of Research and InnovationNational Cancer InstituteEuropean Regional Development FundInstituto de Salud Carlos IIICancer Council NSWCancer Council VictoriaCanadian Cancer Society Research InstituteNorris Cotton Cancer CenterU.S. ArmyHellenic Health FoundationFreistaat SachsenBiomedical Research CouncilFederal Agency for Scientific OrganizationsPomorski Uniwersytet Medyczny W SzczecinieMutuelle Générale de l'Education NationaleInstitut Gustave-RoussyMinistero dello Sviluppo EconomicoUniversidad de OviedoCenter for Agroforestry, University of MissouriOulun YliopistoKWF KankerbestrijdingConseil Régional des Pays de la LoireVetenskapsrådetNational Medical Research CouncilNorges ForskningsrådStockholms Läns LandstingStavros Niarchos FoundationLigue Contre le CancerKuopion Yliopistollinen SairaalaAssociazione Italiana per la Ricerca sul CancroKarolinska InstitutetVanderbilt UniversityKorea Health Industry Development InstituteHungarian Scientific Research FundJapan Agency for Medical Research and DevelopmentDeutsche Gesetzliche UnfallversicherungHerlev HospitalNational Institute of Environmental Health SciencesSwedish Cancer FoundationMinistry of Health, Labour and WelfareUniversity of Southern CaliforniaCancerfondenAmerican Cancer SocietyRadboud UniversiteitCancer AustraliaRussian Foundation for Basic ResearchNational Health and Medical Research CouncilDeutsche KrebshilfeMinistry of Education, Science and TechnologyAcademia SinicaCalifornia Department of Public HealthNational Research Foundation of KoreaNational Natural Science Foundation of ChinaDepartament d'Universitats, Recerca i Societat de la InformacióInstitut National de la Santé et de la Recherche MédicaleProgramme Grants for Applied ResearchOvarian Cancer AustraliaRobert Bosch StiftungFisher Center for Alzheimer's Research FoundationProstate Cancer Foundation of AustraliaFundação de Amparo à Pesquisa do Estado de São PauloCanadian Institutes of Health ResearchEuropean CommissionMedizinischen Hochschule HannoverCancer Institute NSWUniversity College LondonAcademy of FinlandKing's College LondonLon V. Smith FoundationDeutscher Akademischer AustauschdienstHealth CanadaInstytut Medycyny Pracy im. prof. J. NoferaYayasan Sime DarbyNational Institute of Dental and Craniofacial ResearchUniversity of CambridgeNemzeti Kutatási Fejlesztési és Innovációs HivatalVirginia Department of HealthGovernment of CanadaGenome CanadaFred C. and Katherine B. Andersen FoundationGeorgia Clinical and Translational Science AllianceRoyal Marsden NHS Foundation TrustWellcome TrustJohns Hopkins UniversityOntario Institute for Cancer ResearchWorld Cancer Research FundBC Cancer FoundationCancer Care OntarioCancer Research SocietyInstitute of Biomedical Sciences, Academia SinicaDavid F. and Margaret T. Grohne Family FoundationCancer Prevention and Research Institute of TexasHelse VestAssociation Anne de Bretagne GenetiqueCancer Council South AustraliaMemorial Sloan-Kettering Cancer CenterCentre International de Recherche sur le CancerKreftforeningenSundhed og Sygdom, Det Frie ForskningsrådVanderbilt University Medical CenterDeutsches KrebsforschungszentrumPeter MacCallum FoundationFundación para el Fomento en Asturias de la Investigación Científica Aplicada y la TecnologíaHelsingin ja Uudenmaan SairaanhoitopiiriKræftens BekæmpelseDr. Ralph and Marian Falk Medical Research TrustRoswell Park Cancer InstituteCompagnia di San PaoloNational Institutes of HealthGroupement des Entreprises Françaises dans la lutte contre le CancerFlorida Department of HealthDivision of Cancer Prevention, National Cancer InstituteNational Breast Cancer FoundationEuropean Social FundMedical Research CouncilMayo Foundation for Medical Education and ResearchRutgers Cancer Institute of New JerseyJunta de Castilla y LeónSusan G. Komen for the CureTaiwan BiobankProstate Cancer FoundationOak FoundationNational Center for Research ResourcesAvon Foundation for WomenWorld Health OrganizationUniversity of South FloridaNIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer ResearchNational Research FoundationCenters for Disease Control and PreventionNational Institute for Health and Care ResearchNational Cancer Research InstituteU.S. Department of Health and Human ServicesMinisterio de Economía y CompetitividadNational Center for Advancing Translational SciencesBundesministerium für Bildung und ForschungMinistry of Education, Culture, Sports, Science and TechnologyJapan Society for the Promotion of ScienceOvarian Cancer Research FundBreast Cancer CampaignGeorgetown UniversityCancer Council TasmaniaItä-Suomen YliopistoAgency for Science, Technology and ResearchState of Connecticut Department of Public HealthCancer Research InstituteOregon Health and Science UniversityCancer Research UKSheffield Hospitals CharityNordForskU.S. Department of DefenseUniversity of PittsburghBreast Cancer Research FoundationUniversity of Texas MD Anderson Cancer CenterPrincess Margaret Hospital FoundationMoffitt Cancer CenterMinnesota Ovarian Cancer AllianceFonds Wetenschappelijk OnderzoekRoy Castle Lung Cancer FoundationCalifornia Breast Cancer Research ProgramFondation du cancer du sein du Québec
KeywordsHeritabilityComputational biologyBiologyGeneticsEvolutionary biology
Abstract
fetched live from OpenAlexAbstract Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer ( r g = 0.57, p = 4.6 × 10 −8 ), breast and ovarian cancer ( r g = 0.24, p = 7 × 10 −5 ), breast and lung cancer ( r g = 0.18, p =1.5 × 10 −6 ) and breast and colorectal cancer ( r g = 0.15, p = 1.1 × 10 −4 ). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.722
Threshold uncertainty score0.351
Codex and Gemma teacher scores by category
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Teacher spread0.305 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
