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Record W2899649473 · doi:10.1093/geroni/igy023.2790

VARIABILITY MEASURES UNLOCK THE CLINICAL UTILITY OF GAITRITE ASSESSMENT FOR PREDICTING MILD COGNITIVE IMPAIRMENT

2018· article· en· W2899649473 on OpenAlexaff
Timothy V. Lukyn, R. A. Dixon, Stuart MacDonald

Bibliographic record

VenueInnovation in Aging · 2018
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsInstitute of AgingWomen and Children’s Health Research InstituteUniversity of AlbertaUniversity of Victoria
Fundersnot available
KeywordsNormativeLogistic regressionRegressionCognitive impairmentPsychologyRegression analysisCognitionAudiologyClinical psychologyStatisticsMedicineMathematicsPsychiatry

Abstract

fetched live from OpenAlex

This study aimed to establish criterion validity of normative regression GAITRite values for discriminating between amnestic Mild Cognitive Impairment (a-MCI) and cognitively intact controls using a reference sample (N=312, age 69 - 95) of healthy participants from the Victoria Longitudinal Study. Regression norming was used to derive weighted equations which were deployed in a target sample of 34 older adults (a-MCI=12, controls=22, 70–85 years of age). The difference between observed and predicted scores was derived, standardized as T-scores, and then used in logistic regression analyses to classify aMCI and healthy controls. The standardized difference scores for velocity, stride time variability and support base variability while under cognitive load (counting backward by 7’s) yielded a classification accuracy of 93.2% with specificity of 96.9% and sensitivity of 83.3%. This is the first evidence of clinically meaningful classification of aMCI using regression norming values and variability indicators derived from the GAITRite system.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.011
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.054
Threshold uncertainty score0.397

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0110.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.096
GPT teacher head0.452
Teacher spread0.356 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2018
Admission routes1
Has abstractyes

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