IMMUNOGENOMIC RESPONSES TO VACCINATION IN AGING: INSIGHTS INTO IMMUNE RESILIENCE
Bibliographic record
Abstract
Vaccination against influenza and pneumococcus serves to prevent or attenuate the severity of future infections involving these important pathogens. However, viewed from the perspective of physical resilience, vaccination also offers unique opportunities to evaluate the capacity of the immune system to respond to a defined stressor in the form an attenuated antigen. Moreover, growing evidence indicates that humoral and cell-mediated responses may be predictive of future risk of infection, disability or death by offering insights into relevant elements of physical resilience at the level of specific immune responses. In recent studies (AG048023, AG052608; UH2 AG056925), we have begun to explore these issues by leveraging technological advances involving cellular phenotyping and genome-wide sequencing of PBMCs obtained from older adults (Ucar et al. JEM 2017) with the ability to identify older flu vaccine responders versus non-responders using ex vivo responses involving inducible Granzyme B and interferon-gamma/IL10 (McElhaney et al. Front Imm. 2016).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".