IMMUNOGENOMIC RESPONSES TO VACCINATION IN AGING: INSIGHTS INTO IMMUNE RESILIENCE
Bibliographic record
Abstract
Vaccination against influenza and pneumococcus serves to prevent or attenuate the severity of future infections involving these important pathogens. However, viewed from the perspective of physical resilience, vaccination also offers unique opportunities to evaluate the capacity of the immune system to respond to a defined stressor in the form an attenuated antigen. Moreover, growing evidence indicates that humoral and cell-mediated responses may be predictive of future risk of infection, disability or death by offering insights into relevant elements of physical resilience at the level of specific immune responses. In recent studies (AG048023, AG052608; UH2 AG056925), we have begun to explore these issues by leveraging technological advances involving cellular phenotyping and genome-wide sequencing of PBMCs obtained from older adults (Ucar et al. JEM 2017) with the ability to identify older flu vaccine responders versus non-responders using ex vivo responses involving inducible Granzyme B and interferon-gamma/IL10 (McElhaney et al. Front Imm. 2016).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".