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Record W2900171085 · doi:10.1038/s41586-018-0701-2

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

2018· article· en· W2900171085 on OpenAlexaff
Shane J. F. Cronin, Corey R. Seehus, Adelheid Weidinger, Sébastien Talbot, Sonja Reißig, Markus Seifert, Yann Pierson, Eileen McNeill, Maria Serena Longhi, Bruna Lenfers Turnes, Taras Kreslavsky, Melanie Kögler, David Hoffmann, Melita Ticevic, Débora da Luz Scheffer, Luigi Tortola, Domagoj Cikes, Alexander Jaïs, Manu Rangachari, Shuan Rao, Magdalena Paolino, Maria Novatchkova, Martin Aichinger, Lee Barrett, Alban Latrémolière, Gerald Wirnsberger, Guenther Lametschwandtner, Meinrad Busslinger, Stephen Zicha, Alexandra Latini, Simon C. Robson, Ari Waisman, Nick Andrews, Michael Costigan, Keith M. Channon, Günter Weiß, Andrey V. Kozlov, Mark Tebbe, Kai Johnsson, Clifford J. Woolf, Josef Penninger

Bibliographic record

VenueNature · 2018
Typearticle
Languageen
FieldMedicine
TopicAsthma and respiratory diseases
Canadian institutionsUniversité LavalCentre hospitalier de l'Université LavalUniversité de Montréal
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesNational Cancer InstituteNational Institute of Neurological Disorders and StrokeNovo Nordisk FondenBritish Heart Foundation
KeywordsAutoimmunityTetrahydrobiopterinT cellBiologyGTP cyclohydrolase ICell biologyCell growthCancer cellNitric oxideImmunologyImmune systemBiochemistryNitric oxide synthaseCancerEndocrinology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.388
Threshold uncertainty score0.266

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.288
Teacher spread0.281 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations287
Published2018
Admission routes1
Has abstractno

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