BDNF VAL66MET POLYMORPHISM, SEX AND RESILIENCE TO COGNITIVE AND PHYSICAL ACTIVITY DECLINES
Bibliographic record
Abstract
Despite the deleterious effects of aging on brain function, a significant proportion of the population maintain cognitive function even into older age. Allelic variation within the neuroplasticity-related gene, brain-derived neurotrophic factor (BDNF), may predict resiliency to cognitive aging and physical activity decline. Specifically, the BDNF Val66Met polymorphism may interact with biological sex to impact cognition and walking behaviour. To address this, in the Health, Aging and Body Composition study we examined the interaction between sex and BDNF genotype on rate of decline over 10 years in executive functioning and self-reported amount of time spent walking. Results indicate that female carriers of the polymorphism showed the least amount of decline in both executive functioning and amount of walking compared to male carriers and non-carriers of both sexes. This suggests that the BDNF Val66Met polymorphism may infer resiliency to cognitive and physical activity declines in older females only.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".