Super Mechanical Stimuli Responsive Hydrogel: Dynamic Cues for Cell Applications
Bibliographic record
Abstract
In this work, we fabricated a thermosensitive hydrogel based on NIPAM that incorporated an oxygen-permeable hyaluronic acid (HA) polysaccharide unit. The interpenetrating network (IPN) of NIPAM-HA-MA hydrogel was fabricated by using an ultraviolet (UV) cross-linking process. Importantly, we explored the real behavior kinetics of the hydrogel via the mechanical properties of Young's modulus and the shear strain. The mechanical properties were reduced when the temperature was raised from 25 to 35 °C, and lower temperatures increased the rigidity of the IPN gel. This dynamic change occurred because of NIPAM's thermosensitive character. Further, IPN hydrogel exhibits good transparency with the incorporation of MA-HA and this stimuli-responsive hydrogel was biocompatible with a human dermal fibroblasts cell line (HDF). The cells adherence was densest when the temperature reached 37 °C and was reduced when the temperature was lowered to 25 °C. We envision using such hydrogels as mimics of cell-instructive biomaterials in tissue engineering applications.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".