IDDF2018-ABS-0120 The effect of OMEGA-3 fatty acid supplementation on paediatric non-alcoholic fatty liver disease: a meta-analysis of randomised controlled trials
Bibliographic record
Abstract
Background Paediatric non-alcoholic fatty liver disease (NAFLD) is an obesity-related disease with growing prevalence worldwide. While current guidelines recommend lifestyle modification, omega-3 supplementation has been suggested as an emerging therapeutic option. Despite supporting evidence demonstrated among adult NAFLD patients, similar meta-analysis among the paediatric population is lacking. The present review aimed to evaluate the efficacy of omega-3 supplementation among children with NAFLD. Methods A systematic review of all randomised controlled trials (RCT) on NAFLD patients aged 18 or under was conducted using 16 multiple databases including Medline, EMBASE and Cochrane Central Register of Controlled Trials. PRISMA guideline was followed. The search was conducted by two independent reviewers, with discrepancies resolved by the third reviewer. Outcomes were categorised into anthropometric (e.g. body mass index), cardio-metabolic (e.g. triglycerides and insulin resistance) and hepatic outcomes (e.g. liver enzymes). Using mean differences (MD), meta-analysis was conducted on outcomes reported in more than one study using a random-effect model. If only median and inter-quartile ranges were provided, they were transformed into mean and standard deviation before meta-analysis. Heterogeneity was examined using I2 statistics. The Cochrane Collaboration’s tool for assessing the risk of bias was used to examine the quality of the included studies. Results After screening 2962 papers, six papers with 326 subjects from five RCT were included in the present review. The included studies were conducted in Canada, Italy, Poland and Turkey. Omega-3 supplementation significantly increased body mass index z-score (MD=0.09), reduced the levels of serum triglycerides (MD=−9.52) and alanine aminotransferase (ALT) (MD=−12.04), and improved insulin sensitivity (MD of the homeostasis model assessment of insulin resistance=−0.49). Heterogeneity was low (below 30%) across various outcomes, and the study quality was generally high, with three papers having low risks of bias in all six domains. Conclusions To conclude, omega-3 supplementation reduced serum triglycerides and ALT, and improved insulin sensitivity among children with NAFLD. It may act as a potential supplementation for paediatric NAFLD patients. But more trials should be conducted, particularly in Asian regions.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.019 | 0.038 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.019 | 0.021 |
| Bibliometrics | 0.008 | 0.010 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.005 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.055 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".