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Record W2903560100 · doi:10.1136/bmj.k4928

HIV post-exposure prophylaxis (PEP)

2018· article· en· W2903560100 on OpenAlexaff
Mark J. Siedner, Ethan Tumarkin, Isaac I. Bogoch

Bibliographic record

VenueBMJ · 2018
Typearticle
Languageen
FieldMedicine
TopicHIV/AIDS Research and Interventions
Canadian institutionsToronto General HospitalUniversity Health NetworkUniversity of Toronto
Fundersnot available
KeywordsPre-exposure prophylaxisHuman immunodeficiency virus (HIV)MedicinePost-exposure prophylaxisComputer scienceVirologyMen who have sex with menSyphilis

Abstract

fetched live from OpenAlex

### What you need to know A 22 year old man presented to the emergency department for HIV post-exposure prophylaxis (PEP). Twenty six hours previously, he had anal receptive intercourse without a condom with a man of unknown HIV serostatus. He had immediate testing for HIV (using a fourth generation antibody/antigen assay as recommended 12 ), hepatitis B and C serologies, syphilis serology, and urine nucleic acid amplification tests for gonorrhoea and chlamydia. In the emergency department he received a three day supply of combined emtricitabine/tenofovir disoproxil fumarate (TDF/FTC) (one tablet, daily) plus raltegravir (400 mg twice daily). He was referred to be seen urgently in the next three days in an outpatient clinic for continuing management. PEP is a safe and effective HIV prevention modality for people with a recent (within 72 hours) exposure to HIV. People with HIV exposure often present to primary care clinics and emergency departments, so it is useful for non-specialists to have confidence in prescribing PEP. Clinicians caring for people presenting with a recent HIV exposure require knowledge of recommended diagnostic testing after sexual exposure and blood borne exposure, PEP regimens, schedule of short and long term follow-up, and the potential for physical and psychological trauma (eg, in the case of sexual assault). This article offers practical advice and resources for clinicians caring for individuals who present for care after an actual or potential exposure to HIV that …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.067
Threshold uncertainty score0.225

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0670.023

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.357
Teacher spread0.332 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2018
Admission routes1
Has abstractyes

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Same venueBMJSame topicHIV/AIDS Research and InterventionsFrench-language works237,207