PSX-5 Evidences of mitochondrial dysfunction and oxidative stress in newly weaned piglets.
Bibliographic record
Abstract
The period following weaning is characterised by a high incidence of nutritional stress, intestinal disturbances and bacterial infections that led to serious diseases. Mounting evidence indicates that mitochondrial function and oxidative stress are closely related to cellular energetic efficiency, immune response and bacterial pathogenesis. The objective of this study was thus to characterize markers of mitochondrial energy metabolism and oxidative stress status throughout the peri-weaning period. To conduct the study, 30 multiparous sows were inseminated, and litters were standardized to 12 piglets. Selected piglets were assigned to one of two experimental groups: normal birth weight piglets (NBW, 1, 67 ± 0, 08 kg, n = 60) and low birth weight piglets (LBW, 1, 09 ± 0, 01 kg, n = 60). Then, 10 piglets from each group were selected at 14, 21 (weaning), 23, 25, 29 and 35 days of age to collect plasma and organ (liver, intestinal mucosa and kidney) samples. Analysis revealed a significant increase (P < 0.05) in the levels of both oxidative damage to DNA (8-hydroxy-2’-deoxyguanosine, 8-OHdG) and proteins (carbonyls) measured in plasma after weaning. A significant decrease (P < 0.05) in cellular energy level in the form of adenosine triphosphate (ATP) content, known to be produced in mitochondria, was observed in the liver after weaning. This decrease was found to be linked to significantly higher (P < 0.05) mitochondrial activity of major antioxidant glutathione peroxidase (GPx) and superoxide dismutase (SOD) in liver, intestinal mucosa and kidneys of piglets following weaning. Additionally, the level of 8-OHdG in plasma and the concentration of protein carbonyls in liver were found to be higher (P < 0.05) in LBW piglets. These results demonstrate that weaning induces mitochondrial dysfunction and oxidative stress in piglets after weaning and indicate that LBW piglets are more severely affected than their NBW littermates.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".