Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.304 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
INTRODUCTION: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. METHODS: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. RESULTS: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. DISCUSSION: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Alzheimer s & Dementia
- Topic
- Dementia and Cognitive Impairment Research
- Field
- Medicine
- Canadian institutions
- —
- Funders
- European Social FundNational Institute of Biomedical Imaging and BioengineeringNational Institute on AgingSchool of Medicine, New York UniversityNational Institutes of HealthEuropean CommissionGenentechFondation pour la Recherche sur AlzheimerIXICOAlzheimer's Disease Neuroimaging InitiativeStichting DioraphteServierCentre Hospitalier Universitaire de BordeauxUniversiteit AntwerpenSorbonne UniversitéVrije Universiteit AmsterdamUniversité de GenèveUniversité de ToulouseEisaiLunds UniversitetNederlandse Organisatie voor Wetenschappelijk OnderzoekMedpaceBundesministerium für Bildung und ForschungAXA Research FundEli Lilly and CompanyRadboud UniversiteitKarolinska InstitutetAristotle University of ThessalonikiZonMwUniversität HeidelbergUniversity of BristolInstitut National de la Santé et de la Recherche MédicalePfizerEU Joint Programme – Neurodegenerative Disease ResearchAlzheimer NederlandYork UniversityAgence Nationale de la RechercheBiogenBioClinicaAvid RadiopharmaceuticalsUniversiteit MaastrichtF. Hoffmann-La RocheU.S. Department of DefenseItä-Suomen YliopistoRoche NederlandNovartis Pharmaceuticals CorporationBristol-Myers SquibbSynarcMeso Scale DiagnosticsGIESKES-STRIJBIS FONDSAlzheimer's AssociationU.S. Department of Health and Human Services
- Keywords
- DementiaDiseaseCognitive declineAlzheimer's diseaseCognitive reserveCognitionPsychologyMedicineGerontologyPsychiatryInternal medicine
- Has abstract in OpenAlex
- yes