P1489Sustained long term benefits after alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy: a single centre experience
Bibliographic record
Abstract
Background and purpose: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant myocardial disease, characterized by left ventricular hypertrophy and obstruction of the left ventricular outflow tract (LVOT). In symptomatic patients refractory to drug therapy, surgical septal myectomy is traditionally performed as treatment. However, percutaneous alcohol septal ablation (ASA) now exists as a less invasive alternative. We evaluated the long-term outcomes, regarding safety and efficacy, of ASA. We report our retrospective analysis based on a single center experience, with 8 years follow up. Methods: From January 2005 to July 2017, 37 patients with obstructive HCM underwent ASA. All patient data, including procedural and outcome characteristics, were prospectively recorded in a dedicated database. Comparison of continuous values, pre- and post-ASA, were performed using paired sample t-test. Results: There were no procedural related deaths. 5 patients subsequently required septal myectomy and 1 patient received a second ASA. 2 patients died during follow up. One due to cancer and the other to ischemic heart disease. The remaining 30 patients (mean age of 66±10.6, 20 males, 10 females) formed the basis of this study. 5 out of 30 patients (17%) required a permanent pacemaker due to post-ASA complete heart block. 2 patients (7%) developed ventricular fibrillation and required an implantable cardioverter-defibrillator.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".