Preparation, characterization, and antioxidant activities of cellulose nanocrystals/genistein nanocomposites
Bibliographic record
Abstract
Genistein (GEN), a typical isoflavone compound, exhibits desirable pharmacological activities, such as antioxidation, anti-inflammatory, , and anti-cancer properties. However, the pharmaceutical application of GEN is limited because of its poor water solubility in aqueous systems. In this study, cellulose nanocrystals (CNCs) and cetyltrimethylammonium bromide (CTAB)-coated CNCs were used as carriers for GEN to improve its dissolution rate and antioxidant activity in aqueous systems. The CNC/GEN and CNC/CTAB/GEN nanocomposites were successfully prepared and characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, and X-ray diffraction analysis. The results showed that the nanonized GEN performed better and its crystalline structure decreased because of the formation of the CNC/GEN and CNC/CTAB/GEN nanocomposites. The GEN dissolution rates in the CNC/GEN and CNC/CTAB/GEN nanocomposites increased to 72.1% and 92.5% at 120 min, respectively, compared with that of the original GEN (0.85%). Furthermore, the in vitro antioxidant activity of the GEN, which was evaluated by the hydroxyl radical scavenging efficiency, was remarkably enhanced. Based on the above results, CNCs as nanocarriers are a useful method for improving the dissolution and antioxidant activities of GEN in aqueous system.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".