‘Innate and T lymphocyte developmental pathways independent of Common lymphoid progenitors’
Bibliographic record
Abstract
Abstract Lymphocytes are believed to develop from a population of committed lymphoid progenitors termed common lymphoid progenitors (CLPs). However, upstream lymphoid progenitors termed lymphoid-primed multi-potent progenitors (LMPPs) are more efficient than CLPs in differentiating into group 2 innate lymphoid cells (ILC2s) and T cells, suggesting that alternative pathways for the development of these cells exist. In this study, we divided LMPPs into CD127− (LMPP-s) and CD127+ (LMPP+s) subsets and compared them with Ly6D+ and Ly6D− CLPs. Adult LMPP+s differentiated into ILCs and T cells more rapidly and efficiently than other progenitors in transplantation assays. Development of ILC2s and T cells is highly active during neonatal period. In this period CLPs are rare and, unlike prominent neonatal LMPP+s, do not efficiently differentiate into ILC2s and T cells. ILC2s generated in neonates persist in adults. These results suggest that the majority of ILCs and T cells develop from LMPP+s via CLP-independent pathways.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".