Bibliographic record
Abstract
Participants with amnestic Mild Cognitive Impairment (aMCI) do not inevitably show cognitive decline or convert to Alzheimer’s disease (AD) supporting the hypothesis that secondary events are crucial in the conversion process. Research suggests that psychological stress is a risk factor for AD. Therefore, we proposed psychological stress will be associated with worsened cognitive decline, a clinical marker of advancing neurodegeneration. This was a longitudinal observational study assessing the association between the degree of psychological stress and cognitive decline in 134 aMCI participants and 69 control participants. We hypothesised that stress, as measured by the Recent Life Change Questionnaire (RLCQ), would be associated with worsened cognitive decline, as measured by the Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR), over an 18 month follow-up period. Other secondary cognitive outcomes included the difference in change of the Montreal Cognitive Assessment score and the Trail Making Test Part B. Exploratory measures of stress included the Perceived Stress Scale and the presence of physical stressors. Hypothesised modulators of the stress response were assessed including mood, neuroticism, social support, and favoured coping style. Biological outcomes included changes in blood levels of inflammatory markers and salivary cortisol. Objective stressful life events occurring during the course of the study were associated with increased rates of cognitive decline across a range of measures in the aMCI group. Whereas, as predicted, psychological stress was not associated with cognitive decline in the control group. Presence of the ApoE ε4 allele was associated with an increased rate of cognitive decline and increased serum levels of the anti-inflammatory cytokine TGFβ was associated with a slower rate of cognitive decline in the aMCI group. We found that neither measures of mood nor potential modulators of stress exerted a consistent significant influence over rates of cognitive decline in the aMCI group.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".