Free radical scavenging activities of phytochemical mixtures and aqueous methanolic extracts recovered from processed coffee leaves
Why this work is in the frame
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Bibliographic record
Abstract
Summary It is well known that the choice of extraction solvents greatly affects both phytochemical composition and related bioactivity of plant extract. Herein, we show that coffee leaf extracts derived from 80% methanol have no effect on basal nitric oxide production in Raw 264.7 cells, whereas, a different result was observed with a previous hot water extract. Phytochemical mixtures formulated to contain equivalent amounts of CQA s, mangiferin and rutin know to present in coffee leaves showed a relatively low (3.5–18.5%, TPC ; 17.6–31.6%, ABTS ; 7.9–13.6%, DPPH ; and 8.5–29.7%, ORAC ) contribution to antioxidant activities when compared to the coffee leaf extracts. We conclude that the solvent polarity is particularly important to the unique phytochemical mixture recovered, which in turn governs the bioactivity. This study also demonstrated that other phytochemicals in coffee leaves that were not measured in this study are important in assessing total antioxidant activity of this potential plant beverage.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it