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Record W2908541000 · doi:10.1001/jama.2018.17948

Serum Creatinine Levels Before, During, and After Pregnancy

2019· article· en· W2908541000 on OpenAlexafffund
Ziv Harel, Eric McArthur, Michelle Hladunewich, Jade Dirk, Ron Wald, Amit X. Garg, Joel G. Ray

Bibliographic record

VenueJAMA · 2019
Typearticle
Languageen
FieldMedicine
TopicChronic Kidney Disease and Diabetes
Canadian institutionsHealth Sciences CentreWestern UniversitySunnybrook Health Science CentreInstitute for Clinical Evaluative SciencesSt. Michael's Hospital
FundersKidney Foundation of CanadaInstitute for Clinical Evaluative SciencesOntario Ministry of Health and Long-Term CareSchulich School of Medicine and DentistryAcademic Medical Organization of Southwestern OntarioCanadian Institutes of Health ResearchLawson Health Research Institute
KeywordsMedicineRenal functionCreatininePregnancyGestational ageGestationKidney diseaseKidneyInternal medicineObstetricsEndocrinologyUrologyPhysiology

Abstract

fetched live from OpenAlex

Serum Creatinine Levels Before, During, and After PregnancyEstimating renal function before and during pregnancy has clinical importance: kidney dysfunction can affect maternal and perinatal health.Glomerular hyperfiltration is a typical physiological adaptation to pregnancy, reflected by a decrease in levels of serum creatinine (SCr) with advancing gestational age.Creatinine-based equations used to estimate glomerular filtration may misclassify renal function during pregnancy, 1 as they depend on a steady state of creatinine balance.Moreover, a 24-hour collection of urine to measure cre-atinine clearance is impractical. 2Accordingly, physicians typically rely on SCr level.Previous studies attempted to define a normal SCr level in pregnancy, but they had few participants and may have been confounded by sampling bias. 3,4The current study was undertaken to generate gestational age-specific estimates of renal function-before, during, and after pregnancy-among women without antecedent kidney disease.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.012
Threshold uncertainty score0.997

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.239
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations120
Published2019
Admission routes2
Has abstractyes

Explore more

Same venueJAMASame topicChronic Kidney Disease and DiabetesFrench-language works237,207