Metachronous and Synchronous Multiple Primary Carcinomas in an Elderly
Bibliographic record
Abstract
The prognosis of most cancers has been improved in recent years due to the increased survival of cancer patients, the prolonged lifespan of the general population, and better diagnostic and surgical approaches. Subsequently, the number of patients with multiple primary carcinomas (MPCs) has become greater. In this report, we describe a unique case of a 71-year-old man with five metachronous and synchronous primary malignant tumors. The patient was first diagnosed with synchronous, left posterior tonsillar pillar squamous cell carcinoma (SCC) and right lingual surface of epiglottis SCC in June 2016. Two years later, he presented with three other primary carcinomas within a 3-month time span: right lower lobe lung SCC, right tongue invasive SCC and hepatocellular carcinoma (HCC), consecutively. Investigations revealed no metastases of the primary neoplasms. As the population of older adults with cancer and multimorbidity grows, the therapeutic options usually become limited. On the other hand, understanding the effect of multimorbidity on the care of patients with cancer and developing therapeutic interventions for these elderly patients would be crucial for geriatric care. J Med Cases. 2019;10(1):8-13 doi: https://doi.org/10.14740/jmc3172
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".