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Record W2913462228 · doi:10.1016/j.ebiom.2019.02.007

Hepatocellular carcinoma: H-Prune gene regulatory networks

2019· letter· en· W2913462228 on OpenAlexaff
Pasqualino De Antonellis

Bibliographic record

VenueEBioMedicine · 2019
Typeletter
Languageen
FieldMedicine
TopicHepatocellular Carcinoma Treatment and Prognosis
Canadian institutionsSickKids FoundationHospital for Sick Children
Fundersnot available
KeywordsHepatocellular carcinomaEpigenomicsTranscriptomeLiver cancerMedicineCancerHepatitis B virusHepatitis C virusCancer researchBioinformaticsInternal medicineOncologyBiologyDNA methylationGeneVirusGeneticsVirologyGene expression

Abstract

fetched live from OpenAlex

Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancers, which represents the second leading cause of cancer-related deaths globally [1]. HCC results from the accumulation of somatic genomic and epigenomic alterations in the tissue of origin and can be mainly caused by chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV), alcohol abuse, and metabolic syndromes related to diabetes or obesity. Thus far, multi-omics analyses involving genomic, transcriptomic, and/or epigenomic profiling of large cohorts of tumors have provided the basis for the molecular classification of HCC into two, equally represented, distinct subtypes named proliferation class and non-proliferation class.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.027

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0080.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.227
Teacher spread0.188 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2019
Admission routes1
Has abstractyes

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