P103 Degradation and formation of type III, IV and V collagen are associated with disease activity, disease severity and disease extension in patients with ulcerative colitis
Bibliographic record
Abstract
Ulcerative colitis (UC) is an idiopathic chronic inflammatory bowel disease, where increased matrix metalloproteinases are the major contributor to the intestinal tissue remodelling UC. The intestinal basement membrane (main constituent is type IV collagen) is directly positioned underneath the epithelial cells. The supportive interstitial matrix (main constituent are type I, III and V collagens) is mainly produced by fibroblasts. Both matrices are important for intestinal health and are highly affected in UC. We investigated serum biomarkers of collagen degradation and formation of the respective extracellular matrix (ECM) compartments and their association with disease activity, severity and extension in UC. In total, 29 UC patients and 29 healthy donors (HD) were included. A combination of the partial mayo score and biochemical activity was used to determine disease activity (pMayo > 1 and CRP >5). Disease severity and extension was assessed by Montreal classification. Biomarkers of type III collagen degradation (C3M) and formation (PRO-C3), type IV collagen degradation (C4M) and formation (PRO-C4), type V collagen formation (PRO-C5) and C-reactive protein (CRP) were measured in serum by ELISA. One-way ANOVA (Tukey’s multiple comparisons test), and spearman rho correlations were applied for statistical analyses. C4M was significantly elevated in active UC compared with UC in remission (p < 0.05) and HD (p < 0.001), and PRO-C4 was also significantly elevated in active UC compared with UC in remission (p < 0.01) and HD (p < 0.001). C3M was significantly elevated in active UC compared with UC in remission (p < 0.05) and HD (p < 0.05), whereas PRO-C3 was significantly elevated in active UC and UC in remission compared with HD (p < 0.001). PRO-C5 was elevated in active UC compared with HD (p < 0.01). Abstract PO103 – Figure 1. The figure depict type III, IV, and V collagen remodelling in UC, and differences between healthy donors, UC in remission and active UC. In addition, C3M (r = 56, p < 0.01), C4M (r = 0.41, p < 0.05), PRO-C4 (r = 58, p < 0.001), PRO-C5 (r = 49, p < 0.01), and CRP (r = 47, p < 0.01) correlated with disease severity, and PRO-C4 (r = 48, p < 0.01), PRO-C5 (r = 0.38, p < 0.05), and CRP (r = 45, p < 0.01) correlated with disease extension. The biomarkers C3M and C4M were associated with disease activity in UC and disease severity in addition to PRO-C4 and PRO-C5. PRO-C4 and PRO-C5 also correlated with disease extension. These data demonstrated that ECM remodelling of the intestinal basement membrane and interstitial matrix are associated with disease status and progression, which can be used to optimise treatment strategies for UC patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".