P467 Circulating CD8 α4β7+ and CD8b7+ memory T cells as early biomarkers of clinical response to vedolizumab in ulcerative colitis
Bibliographic record
Abstract
Vedolizumab (VDZ) is a humanised monoclonal antibody targeting the α4β7 integrin us in ulcerative colitis (UC). So far, no biomarker of response to VDZ has been identified. To assess whether circulating CD4+ and CD8+ α4β7+/ α4β7- memory T lymphocytes are molecular markers of response to VDZ treatment in patients with UC. Prospective study, 15 patients with active UC (Ulcerative Colitis Disease Activity Index (UCDAI) >3, Mayo endoscopic subscore >1, faecal calprotectin >250 μg/g) and with prior failure to anti-TNFα therapy, starting treatment with VDZ ( 300 mg iv, standard induction regime). Peripheral blood sample obtained just before first dose of VDZ, purification of circulating memory T cells (CD45RO+) and simultaneous analysis of CD CD4+ and CD8+ limphocitic subpopulations (α4β7+/−, HLA-DR+/−, CD25+/−, IL23R+/−, CCR9+/−, IL17A+/−, IL-23R+/−, IL-9+/−, β7 +/−) by flow citometry. Clinical response and remission (UCDAI clínic) and faecal calprotectin levels were evaluated at Weeks 6 and 14. Eight females, age 46 ± 16 years extent (Montreal E1: 2 patients, E2: 8 patients, and E3: 5 patients), 7 severe colitis (UCDAI > 9). At Week 6: 9 patients were in clinical response, 7 patients were in clinical remission and 8 patients had faecal calprotectin levels <250 μg/g. At Week 14 : 10 patients remained in clinical response , 8 were in clinical remission and 10 patients had faecal calprotectin levels <250 μg/g. Patients with clinical response, clinical remission and faecal calprotectin levels < 250 μg/g at Week 6; and clinical remission and faecal calprotectin levels < 250 μg/g at Week 14, presented an absolute account of CD8 α4β7+ and CD8b7+ memory T cells at baseline significantly higher when compared with patients with no VDZ response (Table 1). No differences were identified according to the severity of the flare or the extent of the disease. No statistically significant differences were identified in the other lymphocyte subpopulations included in the study. The absolute account of CD8 α4β7+ and CD8b7+ memory T cells before starting VDZ treatment could be early biomarkers of clinical response, allowing to select a subset of patients that are more likely to respond to VDZ.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".