Primary biliary cholangitis and its association with other autoimmune diseases in a Mexican cohort
Bibliographic record
Abstract
Primary biliary cholangitis and its association with other autoimmune diseases in a Mexican cohort ଝ Colangitis biliar primaria y su asociación con otras enfermedades autoinmunes en una cohorte mexicana Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease, secondary to biliary epithelial cell damage that causes destruction of the small and medium-caliber interlobular and septal bile ducts. 1 The natural history of PBC is characterized by different phases.The first is the preclinical phase, in which there is only evidence of antimitochondrial antibodies (AMAs).The asymptomatic phase follows, with an elevated alkaline phosphatase level, which can then progress to a symptomatic phase, predominantly characterized by fatigue and pruritus.The last phase is the terminal phase, in which complications associated with the development of cirrhosis of the liver are present.2 The pathogenesis of PBC is not fully understood, but it is thought to be multifactorial.The participation of genetic, epigenetic, environmental, and even infectious factors appears to be necessary for its development.Therefore, the study of risk factors, as well as the association with other nonhepatic autoimmune diseases in different geographic areas, is most relevant.In the present study conducted by González-Huezo et al., 3 78 patients diagnosed with PBC at a tertiary care hospital in central Mexico were retrospectively evaluated.The authors previously excluded 36 patients due to incomplete clinical data or diagnosis of PBC-autoimmune hepatitis overlap syndrome.Similar to that reported in other case series, the prevalence of AMAs, antinuclear antibodies (ANAs), and anti-smooth muscle antibodies (ASMAs) was 95, 71, and
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".