IL-2 induces apoptosis, increases the production and expression of cytochrome-C and inhibits COX IV in cervical cancer cells
Bibliographic record
Abstract
It is known that cervical cancer cells express IL-2 receptor (IL-2R) and those high doses induce cell death. To identify the type of cell death two cervical cancer cell lines, CALO and INBL, were cultured with 100 IU/ml of IL-2. Our results showed the presence of apoptotic cell death by the significant expression of phosphatidylserine on the external surface of cellular membranes, the presence of a typical DNA fragmentation and the activation of caspase 3. We also observed that the expression of COX I, COX II and COX III was not significantly altered while that of COX IV was completely inhibited. An increased expression of cytochrome-C by confocal microscopy was observed. Finally, we speculate that the clinical effect and toxicities of IL-2 used in cancer therapies is mostly due to its apoptotic effect on the cancer cells themselves rather than, as thought, the cytotoxic contribution of leukocytes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".