← Back to cohort
Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial
Gil I. Wolfe, Henry J. Kaminski, Inmaculada Aban, Greg Minisman, Hui‐Chien Kuo, Alexander Marx, Philipp Ströbel, Claudio Mazia, Joël Oger, Gabriel Cea, Jeannine M. Heckmann, Amelia Evoli, Wilfred A. Nix, Emma Ciafaloni, Giovanni Antonini, Rawiphan Witoonpanich, John King, Said R. Beydoun, Colin Chalk, Alexandru Barboi, Anthony A. Amato, Aziz Shaibani, Bashar Katirji, Bryan Lecky, Camilla Buckley, Angela Vincent, Elza Dias‐Tosta, Hiroaki Yoshikawa, Márcia Waddington‐Cruz, Michael Pulley, Michael H. Rivner, Anna Kostera‐Pruszczyk, Robert M. Pascuzzi, Carlayne E. Jackson, Jan J.G.M. Verschuuren, Janice M. Massey, John T. Kissel, Lineu César Werneck, Michael Benatar, Richard J. Barohn, Rup Tandan, Tahseen Mozaffar, Nicholas J. Silvestri, Robin Conwit, Joshua Sonett, Alfred Jaretzki, John Newsom–Davis, Gary Cutter, Michelle Feese, Valeria Saluto, Moisés Rosenberg, Valeria Alvarez, Lisa A. Rocca Rey, Helmut Butzkueven, John Goldblatt, John C. Carey, John R. Pollard, Stephen Reddel, Nicholas Handel, Brian C. McCaughan, Linda Pallot, Ricardo Novis, Carlos Henrique Ribeiro Boasquevisque, Rubens N. Morato-Fernandez, Manoel Ximenes, Rosana Hermínia Scola, Paulo Soltoski, Fraser Moore, David S. Mulder, Lisa Wadup, Michele Mezei, Kenneth G. Evans, Theresa Jiwa, Anne Schaffar, Chris White, Cory Toth, Gary Gelfand, Susan P. Wood, Elizabeth Pringle, Jocelyn Zwicker, Donna E. Maziak, Farid M. Shamji, Sudhir Sundaresan, Andrew Seely, Renato Verduga, Alberto Aguayo, Sebastian Jander, Philipp Zickler, Michael D. Klein, Cleo‐Aron Weis, Arthur Melms, Felix Bischof, Hermann Aebert, Gerhard Ziemer, Björn Thümler, Thomas Wilhem-Schwenkmezger, Eckhard Mayer, Berthold Schalke, Peter Pöschel, Gisela Hieber, Karsten Wiebe, Alessandro Clemenzi, V. Ceschin, Erino Angelo Rendina, Federico Venuta, Stefania Morino, Elisabetta Bucci, Luca Durelli, A. Tavella, Marinella Clerico, Giulia Contessa, P. Borasio, Serenella Servidei, Pierluigi Granone, Renato Mantegazza, E. Berta, L. Novellino, Luisa Spinelli, Masakatsu Motomura, Hidenori Matsuo, Takeshi Nagayasu, Masaharu Takamori, Makoto Oda, Isao Matsumoto, Yutaka Furukawa, Daisuke Noto, Yuko Motozaki, Kazuo Iwasa, Daisuke Yanase, Guillermo García Ramos, Lorenzo de la Garza, Marta Lipowska, Hubert Kwieciński, Anna Potulska‐Chromik, Tadeusz Orłowski, Ana Silva, Marta Feijo, Antônio Hilário Alves Freitas, A. Frost, Edward Pan, Lawrence Tucker, Johan Rossouw, Fiona Drummond, Isabel Illa, Jorge Díaz, Carlos León, Jiann‐Horng Yeh, Hou‐Chang Chiu, Yei‐San Hsieh, Supoch Tunlayadechanont, Sukasom Attanavanich, C.S.M. Straathof, Maarten J. Titulaer, Michel I.M. Versteegh, Arda Pels, Yvonne Krum, Maria Isabel Leite, David Hilton‐Jones, C Ratnatunga, Maria Elena Farrugia, Richard Petty, James Overell, Alan Kirk, Andrew Gibson, Christopher McDermott, David Hopkinson, David Watling, Dot Marshall, Sam Saminaden, Deborah Davies, Charlotte F. Dougan, Siva Sathasivam, Richard L. Page, Jon Sussman, John Ealing, P. Krysiak, Anthony A. Amato, Mohammad Salajegheh, Michael T. Jaklitsch, Kristen Roe, Tetsuo Ashizawa, Robert G. Smith, Joseph Zwischenberg, Penny Stanton, Safwan Jaradeh, William B. Tisol, Mario Gasparri, George B. Haasler, Mary Yellick, Cedric Dennis, Mamatha Pasnoor, Mazen M. Dimachkie, April McVey, Gary Gronseth, Arthur Dick, Jeffrey B. Kramer, Melissa Currence, Laura Herbelin, Jerry M. Belsh, George Li, John Langenfeld, Mary Ann Mertz, Michael Benatar, Taylor Harrison, Seth Force, Sharon Usher, Frank Y. Lin, Steve R. DeMeester, Salem Akhter, Ali Malekniazi, Gina Avenido, Brian A. Crum, Margherita Milone, Stephen D. Cassivi, Janet Fisher, Chad Heatwole, Thomas D. Watson, James Hilbert, Alexis M. Smirnow, B. Jane Distad, Michael D. Weiss, Douglas Wood, Joanna Haug, Raina M. Ernstoff, Jingyang Cao, Gary W. Chmielewski, Robert Welsh, Robin Duris, Laurie Gutmann, Gauri Pawar, Geoffrey M. Graeber, Patricia Altemus, Christopher Nance, Ludwig Gutmann, Patrick Grogan, John Calhoon, Pamela Kittrell, Deborah L. Myers, Ghazala Hayat, Keith S. Naunheim, Susan Eller, Eve Holzemer, Amer Alshekhlee, Jason Robke, Brenda Karlinchak, Jonathan Katz, Robert G. Miller, Ralph Roan, Dallas Forshew, Bakri Elsheikh, Patrick Ross, Sharon Chelnick, Richard A. Lewis, Agnes Acsadi, Frank A. Baciewicz, Stacey Masse, Vern C. Juel, Mark W. Onaitis, James Lowe, Bernadette Lipscomb, Gaby Thai, Jeffrey C. Milliken, Verónica Puertas‐Martín, Ronnie Karayan, Suraj Muley, G. Parry, Sara J. Shumway, Shin J. Oh, Gwen C. Claussen, Lu Liang, Robert J. Cerfolio, Angela M. Young, Marla Morgan, John Kincaid, Kenneth A. Kesler, Sandy Guingrich, Angi Michaels, Lawrence H. Phillips, Ted M. Burns, David H. Jones, Cindy R. Fischer, Alan Ross Berger, Harry J. D’Agostino, Lisa Smith, J. Ned Pruitt, Kevin Landolfo, Demetric Hillman, Angelo Sermas, Ross Ruel, Farah Ismail, Mark Sivak, Martin Goldstein, Jorge Camunas, Joan Bratton, Hill Panitch, Bruce J. Leavitt, Marilee Jones, Srikanth Muppidi, Steven Vernino, Sharon Nations, Dan M. Meyer, Nina Gorham
Bibliographic record
VenueThe Lancet Neurology · 2019
Typearticle
Languageen
FieldMedicine
TopicMyasthenia Gravis and Thymoma
Canadian institutionsMcGill UniversityUniversity of British Columbia
FundersNational Institute of Neurological Disorders and StrokeNational Center for Advancing Translational SciencesUniversity of Texas Health Science Center at San AntonioMyasthenia Gravis Foundation of AmericaCSL BehringUniversity of KansasInstitute for Clinical and Translational Research, University of Wisconsin, MadisonMuscular Dystrophy AssociationAlexion Pharmaceuticals
KeywordsPrednisoneThymectomyMyasthenia gravisMedicineEdrophoniumRepetitive nerve stimulationOcular myastheniaAdverse effectClinical trialClinical endpointInternal medicineSurgeryPediatrics
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.025
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.004 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.007 | 0.006 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.004 | 0.006 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.009
GPT teacher head0.241
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations223
Published2019
Admission routes1
Has abstractno