Bibliographic record
Abstract
ABSTRACT Impaired gastrointestinal motility underlies a multitude of digestive complaints. Metoclopramide, an antidopaminergic and cholinomimetic agent, was the first prokinetic drug used to treat such conditions, but a high incidence of adverse effects has limited its use, especially in infants. Domperidone, the second prokinetic drug marketed in Canada, is a potent peripheral dopamine receptor antagonist which does not cross the blood-brain barrier well and, therefore, displays minimal CNS side effects. Cisapride is a gastroprokinetic agent which appears to act mainly by releasing acetylcholine from the myenteric plexus of the gut. It has no dopamine-blocking activity, and does not share the serious CNS side effects of other drugs in its class. These drugs stimulate gastric and small intestinal activity, but cisapride also enhances colonic motility. Cisapride is well tolerated, and seems to exhibit a more favourable benefit-risk ratio than metoclopramide or domperidone. Further studies will determine the relative place of cisapride in the treatment of GI motility disorders. RESUME Une motilite gastro-intestinale pathologique est le signe d'une multitude de maladies digestives. Le metoclopramide, un agent anti-dopaminergique et cholinomimetique, fut le premier medicament procinetique utilise pour traiter de telles conditions mais une frequence elevee des reactions indesirables a limite son usage, surtout chez les nourrissons. Le domperidone, le deuxieme medicament procinetique commercialise au Canada, est un antagoniste puissant des recepteurs dopaminergiques peripheriques qui ne traverse pas beaucoup la barriere hemo-encephalique et donc, provoque peu d'effets secondaires au systeme nerveux central (SNC). Le cisapride est un nouvel agent gastro-procinetique qui semble agir principalement par la liberation de l'acetylcholine du plexus myenterique de l'intestin. Il ne bloque pas la dopamine, donc n'apporte aucun effet secondaire serieux au SNC. Ces medicaments stimulent la motilite gastrique et celle de l'intestin grele, mais en plus, le cisapride augmente la motilite du colon. Le cisapride est bien tolere et semble posseder un rapport avantage; risque plus favorable que le metoclopramide et le domperidone. D’autres etudes determineront la place respective du cisapride dans le traitement des troubles de la motilite GI (gastro-intestinale).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".