Adjuvant Systemic Treatment of Premenopausal Women With Hormone Receptor–Positive Early Breast Cancer: Lights and Shadows
Bibliographic record
Abstract
Research has shown premenopausal women with hormone receptor–positive (HR+) early breast cancer who experience chemotherapy-induced amenorrhea (CIA) have reduced risk of recurrence compared with those who have no CIA, whether treated with adjuvant chemotherapy alone or followed by tamoxifen. Younger premenopausal women, in particular those younger than 35 years, are less likely to experience CIA and have increased risk of recurrence. The Suppression of Ovarian Function Trial (SOFT) tested whether women with HR+ breast cancer who remained premenopausal after chemotherapy, and those never receiving chemotherapy, benefit from adding ovarian function suppression (OFS) to 5 years of tamoxifen treatment, or from use of the aromatase inhibitor (AI) exemestane with OFS. The companion Tamoxifen and Exemestane Trial (TEXT) tested the benefit of exemestane versus tamoxifen for women receiving adjuvant OFS, with or without chemotherapy.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".