Clinical, Laboratory, and Molecular Markers of Type 1 von Willebrand Disease
Bibliographic record
Abstract
Type 1 von Willebrand disease (VWD) is the most common form of this highly prevalent inherited bleeding disease. The condition represents a partial quantitative deficiency of von Willebrand factor (VWF), in which the protein has normal function and shows only subtle structural abnormalities. The clinical manifestations of type 1 VWD are extremely variable. At one extreme, women with a moderately severe VWF deficiency state (plasma VWF levels < 0.25 IU/dL) may experience significant menorrhagia, while in contrast, men with a mild deficiency state may remain asymptomatic throughout life. The key element to the laboratory diagnosis of type 1 VWD is the demonstration of reduced plasma levels of VWF. The VWF antigen and ristocetin cofactor levels (as a measure of VWF function) will usually be reduced proportionately between 0.05 and 0.50 IU/dL, and the factor VIII (FVIII) coagulant level will also often be low. Preliminary genetic analysis of type 1 VWD indicates that the disease is the consequence of many different mutations both within the VWF gene and at other genetic loci.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".