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Record W2916403930 · doi:10.1289/isee.2015.2015-7559

Challenges Posed By Manganese Neurotoxicity In Latin America

2015· article· en· W2916403930 on OpenAlexaff
Donna Mergler

Bibliographic record

VenueISEE Conference Abstracts · 2015
Typearticle
Languageen
FieldEnvironmental Science
TopicHeavy Metal Exposure and Toxicity
Canadian institutionsUniversité du Québec à Montréal
Fundersnot available
KeywordsManganeseNeurotoxicityLatin AmericansEnvironmental healthBiologyPhysiologyMedicineToxicityChemistryPolitical science

Abstract

fetched live from OpenAlex

In Latin America, several sources of environmental airborne and waterborne manganese have been identified, including manganese mining and transformation, use of manganese-based pesticides and drinking water. Studies have shown negative associations between hair manganese and cognitive function and positive associations with behavioral problems. Manganese is an essential element and as such, the study of its neurotoxicity poses several challenges, both physiologically and socially. Manganese requirements vary with sex and over the life cycle; women of childbearing age have the highest concentrations of blood manganese and they increase further during gestation. Both human and animal studies have shown sex-dependent differences in manganese neurotoxicity, which as well may differ through the lifespan. Manganese is further influenced by iron intake and metabolism, making it not only an issue of physiological interaction, but also of social inequality. In many Latin American countries, the prevalence of anemia surpasses 30% in pre-school children. This presentation will examine how studies on manganese neurotoxicity from Mexico, Ecuador, Costa Rica, and Brazil address these factors and make recommendations for future work, with a view to reduction of exposure and effects.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.099
Threshold uncertainty score0.196

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.002
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.084
GPT teacher head0.272
Teacher spread0.188 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2015
Admission routes1
Has abstractyes

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