Podocalyxin is required for maintaining blood–brain barrier function during acute inflammation
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Significance This article demonstrates a role for podocalyxin in blood–brain barrier (BBB) function. Podocalyxin expression on endothelial cells promotes the formation of adhesion interactions and barrier formation. Furthermore, it describes a neuroelectric phenotype elicited by a selective protease-activated receptor-1 (PAR-1) agonist. PAR-1 activation by serum proteases (e.g., thrombin) leaking into the central nervous system during inflammation has the potential to impact the course of brain injury and recovery. However, the role of PAR-1 in the pathophysiology of neuroinflammation is poorly understood. In summary, this study offers unique insight into the impact of PAR-1 activation in neuroinflammation and implicates podocalyxin as a therapeutic target for the manipulation of BBB permeability and the treatment of neurodegenerative disease.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it