Glycine Regulates Neural Stem Cell Proliferation During Development via Lnx1-Dependent Notch Signaling
Bibliographic record
Abstract
During development of the zebrafish embryo, glycine signaling promotes the differentiation of neural stem cells. We found that glycine signaling suppresses the expression of Ligand of Numb X1 (lnx1), a gene of unknown function during neural stem cell differentiation that is selectively expressed in the embryonic central nervous system. As a consequence, Numb levels were stabilised and Notch activity (measured as her4.1 expression) was reduced, promoting neural stem cell differentiation. These consequent actions were blocked by knockdown of lnx1. In contrast, lnx1 overexpression increased neural stem cell proliferation and led to defects of neural tube closure at early stage of development. Thus, our data provide evidence that glycine/lnx1 signaling modulates neural stem cell proliferation by regulation of Notch signaling.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".