Sex Differences in Cortical Astroglia Throughout Postnatal Development
Bibliographic record
Abstract
Sexual differentiation is a well characterized phenomena of the mammalian central nervous system. There are many structural and functional sex differences characterized throughout the brain and have been well studied. Unfortunately, less well understood is the sexually dimorphic prevalence of psychiatric, neurological, and mood and anxiety disorders in the human population. Many of which have developmental etiologies coinciding with organization of the neocortex. The developmental trajectory of the neocortex has a distinct and well understood temporal and mechanistic patterns. Astroglial cells are fundamental in neocortical development by facilitating radial neuron migration, synaptic maturation and pruning in addition to their neurogenic potential. Sexual dimorphism of astroglial and cells in the neocortex has not been studied. This study examines the phenotypic changes of cortical astroglial cells in postnatal development of both sexes. Although our study yields mixed results, the neurogenic potential of cortical astroglia is sexually dimorphic in the perinatal period.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".